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Hepatocellular carcinoma [PDF]
Nature Reviews Disease Primers, 2021 Liver cancer remains a global health challenge, with an estimated incidence of >1 million cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and accounts for ~90% of cases. Infection by hepatitis B virus and hepatitis C virus are the main risk factors for HCC development, although non-alcoholic steatohepatitis ...
Llovet, Josep M. +9 more
openaire +4 more sources
Hepatocellular carcinoma [PDF]
Nature Reviews Disease Primers, 2016 Liver cancer is the second leading cause of cancer-related deaths globally and has an incidence of approximately 850,000 new cases per year. Hepatocellular carcinoma (HCC) represents approximately 90% of all cases of primary liver cancer. The main risk factors for developing HCC are well known and include hepatitis B and C virus infection, alcohol ...
Llovet, Josep M. +6 more
+10 more sources
New England Journal of Medicine, 2012 Hepatocellular carcinoma is the sixth most prevalent cancer and the third most frequent cause of cancer-related death. Patients with cirrhosis are at highest risk of developing this malignant disease, and ultrasonography every 6 months is recommended. Surveillance with ultrasonography allows diagnosis at early stages when the tumour might be curable by
Emmanuel A, Tsochatzis +2 more
+11 more sources
Hepatocellular carcinoma [PDF]
British Journal of Cancer, 2001 The number of papers published regarding hepatocellular carcinoma between 1999 and 2001 increased from previous years. This year a study confirmed the increase in incidence in the United States. Also, several studies established for the first time that tobacco smoking was a risk factor for the development of this tumor. Several studies established that
Giovannini, M +4 more
openaire +4 more sources
Resveratrol protects against chronic alcohol-induced liver disease in a rat model
STEMedicine, 2022 Hepatic ethanol metabolism participates in the pathogenesis of alcoholic liver disease (ALD). We aimed to evaluate the protecting effects and underlying mechanisms of Resveratrol against ALD.
Hanzhang Zhu +3 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence.
Chuanzheng Wang +7 more
doaj +1 more source
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.
New England Journal of Medicine, 2020 BACKGROUND The combination of atezolizumab and bevacizumab showed encouraging antitumor activity and safety in a phase 1b trial involving patients with unresectable hepatocellular carcinoma. METHODS In a global, open-label, phase 3 trial, patients with
R. Finn +20 more
semanticscholar +1 more source
Hepatology Research, 2023 The fifth version of the Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence‐based medicine and partly to the Grading of Recommendations Assessment ...
K. Hasegawa +26 more
semanticscholar +1 more source
Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma.
NEJM Evidence, 2022 Tremelimumab/Durvalumab for Hepatocellular CarcinomaThis trial examined overall survival (OS) with tremelimumab plus durvalumab, durvalumab alone, or sorafenib in untreated patients with hepatocellular cancer who were not candidates for locoregional ...
G. Abou-Alfa +30 more
semanticscholar +1 more source
Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK
Cell Death Discovery, 2023 HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear.
Xuesong Cen +9 more
doaj +1 more source