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Hepatocellular carcinoma [PDF]
Nature Reviews Disease Primers, 2021 Liver cancer remains a global health challenge, with an estimated incidence of >1 million cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and accounts for ~90% of cases. Infection by hepatitis B virus and hepatitis C virus are the main risk factors for HCC development, although non-alcoholic steatohepatitis ...
Josep M Llovet +2 more
exaly +7 more sources
Hepatocellular carcinoma [PDF]
Current Treatment Options in Oncology, 2000 Early detection of hepatocellular carcinoma (HCC) is feasible, particularly in patients known to be at risk from chronic hepatitis and chronic liver disease. The optimal surveillance strategy is unknown. HCC usually presents as an incurable disease even when detected on surveillance. Surgical resection is the treatment of choice, but the coexistence of
LENCIONI, RICCARDO ANTONIO +2 more
+18 more sources
Hepatocellular carcinoma [PDF]
Anales del Sistema Sanitario de Navarra, 2016 Liver cancer is the second leading cause of cancer-related deaths globally and has an incidence of approximately 850,000 new cases per year. Hepatocellular carcinoma (HCC) represents approximately 90% of all cases of primary liver cancer. The main risk factors for developing HCC are well known and include hepatitis B and C virus infection, alcohol ...
Llovet, Josep M. +6 more
+9 more sources
Journal of Translational Medicine, 2023 Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence.
Chuanzheng Wang +7 more
doaj +1 more source
Resveratrol protects against chronic alcohol-induced liver disease in a rat model
STEMedicine, 2022 Hepatic ethanol metabolism participates in the pathogenesis of alcoholic liver disease (ALD). We aimed to evaluate the protecting effects and underlying mechanisms of Resveratrol against ALD.
Hanzhang Zhu +3 more
doaj +1 more source
Hepatocellular carcinoma [PDF]
Current Opinion in Gastroenterology, 2001 The number of papers published regarding hepatocellular carcinoma between 1999 and 2001 increased from previous years. This year a study confirmed the increase in incidence in the United States. Also, several studies established for the first time that tobacco smoking was a risk factor for the development of this tumor. Several studies established that
M M, Chokshi, J A, Marrero
+7 more sources
Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK
Cell Death Discovery, 2023 HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear.
Xuesong Cen +9 more
doaj +1 more source
RBCK1 promotes hepatocellular carcinoma metastasis and growth by stabilizing RNF31
Cell Death Discovery, 2022 RNF31 (HOIP), RBCK1 (HOIL-1L), and SHARPIN are subunits of the linear ubiquitin chain assembly complex. Their function and specific molecular mechanisms in hepatocellular carcinoma (HCC) have not been reported previously.
Xijun Chen +5 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2017 Long noncoding RNAs (lncRNAs) are a new class of regulatory noncoding RNAs. Emerging evidences indicate that lncRNAs play a critical role in the development of hepatocellular carcinoma (HCC).
Cheng-Rong Xie +10 more
doaj +1 more source
Frontiers in Oncology, 2021 Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there is a lack of tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in clinical form) selectively kill NADPH:
Wenxiu Zhao +15 more
doaj +1 more source