Results 1 to 10 of about 349,711 (241)

ARHGAP4 promotes growth of hepatocellular carcinoma cells by regulating HK2 expression

Zhongguo aizheng zazhi, 2020
Background and purpose: Rho GTPase activating protein 4 (ARHGAP4) is closely related to tumor progression, and has important regulatory effects on tumor cell malignant proliferation.
欧阳晓春, 邹叶青, 李玉梅, 丁小兵   +3 more
doaj  

Hook1 inhibits malignancy and epithelial–mesenchymal transition in hepatocellular carcinoma

Tumor Biology, 2017
Hook1 is a member of the hook family of coiled-coil proteins, which is recently found to be associated with malignant tumors. However, its biological function in hepatocellular carcinoma is yet unknown.
Xu Sun, Qi Zhang, Wei Chen, Qida Hu, Yu Lou, Qi-Han Fu, Jing-Ying Zhang, Yi-Wen Chen, Long-Yun Ye, Yi Wang, Shang-Zhi Xie, Li-Qiang Hu, Ting-Bo Liang, Xue-Li Bai   +13 more
doaj   +1 more source

SIRT3 functions as a tumor suppressor in hepatocellular carcinoma

Tumor Biology, 2017
Hepatocellular carcinoma is one of the leading causes for cancer-related mortality worldwide. SIRT3 may function as either oncogene or tumor suppressor in a panel of cancers; however, the role of SIRT3 in hepatocellular carcinoma remains unclear. In this
Xianchun Zeng, Nanzhu Wang, Hui Zhai, Rongpin Wang, Jiahong Wu, Wei Pu   +5 more
doaj   +1 more source

Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.

PLoS ONE
As a novel genetic biomarker, the potential role of SH3D21 in hepatocellular carcinoma remains unclear. Here, we decipher the expression and function of SH3D21 in human hepatocellular carcinoma. The expression level and clinical significance of SH3D21 in
Wangxia Tong, Na Qin, Tao Lu, Li Liu, Rong Liu, Jibing Chen, Ning Luo   +6 more
doaj   +1 more source

Organelle-Partitioned Sugar–Rhodamine Diad for In Vivo Tumor Imaging

ACS Omega, 2020
Enkang Zhang, Chaozhang Yu, Hui Tang, Yuntong Li, Dongliang Zuo, Rongshui Yang, Chao Ma, Jiayin Miao, Pingguo Liu, Xinhui Su   +9 more
doaj   +1 more source

HCC-Check: A Novel Diagnostic Tool for Early Detection of Hepatocellular Carcinoma Based on Cytokeratin-1 and Epithelial Membrane Antigen: A Cross-Sectional Study

Technology in Cancer Research & Treatment
Background: Hepatocellular carcinoma is frequently diagnosed in advanced stages, leading to a poorer prognosis. Therefore, early diagnosis and identification of biomarkers may significantly improve outcomes.
Kareem A. Attallah MSc, Mohamed S. Albannan PhD, Khaled Farid MD, PhD, Sherine M. Rizk PhD, Nevine Fathy PhD   +4 more
doaj   +1 more source

Hsa-miR-423-5p selectively loaded in hypoxic exosomes reduces the sensitivity of normoxic hepatocellular carcinoma to sorafenib via autophagy

Cancer Cell International
Background For patients with advanced hepatocellular carcinoma, sorafenib is considered a highly effective targeted molecular drug; however, sorafenib resistance limits its therapeutic efficacy.
Bian Shu, Min Zou, Rui Liao, Diguang Wen, Xianzhi Gao, Jiao Lu, Hua Song, Ziyi Sheng, Zuojin Liu, Yu You   +9 more
doaj   +1 more source

Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features

Clinics
OBJECTIVE To investigate immunohistochemical markers of angiogenesis and their association with pathological prognostic features in hepatocellular carcinoma and cirrhotic liver.
Osmar Damasceno Ribeiro, Nathalie Henriques Silva Canedo, Vera Lucia Pannain   +2 more
doaj   +1 more source

Prediction of potential targets of aloe-emodin in the treatment of hepatocellular carcinoma using network pharmacology combined with bioinformatics

Discover Oncology
Background Hepatocellular carcinoma is one of the most common and malignant tumors worldwide. Although aloe-emodin (AE), a pure natural drug, can effectively kill hepatocellular carcinoma cells, its internal molecular mechanism has not been fully ...
Jinlong Wei, Haosong Chen, Maoqi Xu, Zhenglin Zhang, Jin Wang, Wen Jiang, Weiguo Zhou, Maoming Xiong   +7 more
doaj   +1 more source

USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity

Clinical and Translational Medicine
Background Hepatocellular carcinoma remains one of the most lethal cancers, characterized by poor prognosis and low life expectancy. Unfortunately, there are very few molecular therapeutic options available for it.
Xiaochen Wang, Yijie Su, Bei Lan, Xuanyuan Li, Bodi Zhang, Liang Zhang, Yingmei Wang, Chunze Zhang, Chenghao Xuan   +8 more
doaj   +1 more source