Results 51 to 60 of about 633,124 (253)

Molecular drivers of lobular carcinoma in situ [PDF]

, 2015
Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC).
Peter C. Lucas, Daniel D. Brown, Lucas, PC, Clark, Beth Z., McAuliffe, Priscilla F., Greg GregJ. Logan, Rachel C. Jankowitz, Beth Z. Clark, Priscilla F. McAuliffe, Oesterreich, S, Steffi Oesterreich, McAuliffe, PF, Brown, Daniel D., Oesterreich, Steffi, Lucas, Peter C., Jankowitz, RC, Logan, Greg J., Logan, GJ, Jankowitz, Rachel C., Dabbs, DJ, Dabbs, David J., Clark, BZ, Brown, DD, David J. Dabbs   +23 more
core   +1 more source

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy

Oncology and Therapy, 2019
Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carcinoma
Jocelyn Luveta, Ruth M. Parks, David M. Heery, Kwok-Leung Cheung, Simon J. Johnston   +4 more
doaj   +1 more source

Pathology of atypical lobular hyperplasia and lobular carcinoma in situ [PDF]

, 2003
The term lobular neoplasia refers to a spectrum of lesions featuring atypical lobular hyperplasia and lobular carcinoma in situ (LCIS). The histopathological characteristics of these lesions are well documented.
Reis-Filho, Jorge S., Simpson, Peter T., Lakhani, Sunil R., Gale, Theodora, Fulford, Laura G.   +4 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Discrimination of invasive ductal and lobular carcinoma of the breast based on the combination of enhanced Legendre polynomial, kinetic features and deep learning features [PDF]

The fifth most common cause of cancer-related deaths among women worldwide is breast cancer, which is the most common cancer among women globally. Early detection of breast cancer through regular screenings and awareness of symptoms can lead to better ...
Al-Waely, N. K. N., Aljobouri, H. K., Rabha W. Ibrahim, R. W., Jalab, H. A., Hasan, A. M., Meziane, F.   +5 more
core   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Mastite lobular granulomatosa: relato de caso [PDF]

, 2009
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Tonello, Elizabeth Fillard
core  

Case Report: Ductal Carcinoma in Situ Within A Granulomatous Mastitis

European Journal of Breast Health, 2018
Granulomatous lobular mastitis is a rare chronic breast disease, firstly described by Kessler and Wolloch in 1972. In this article we present a 35-yearold patient with granulomatous lobular mastitis and in situ ductal carcinoma and discuss ...
Mine Özşen, Şahsine Tolunay, M. Şehsuvar Gökgöz   +2 more
doaj   +1 more source