Results 51 to 60 of about 152,669 (311)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan

, 2014
Objective: To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. Methods: The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National ...
鄭文芳 ;賴美淑 ;陳祈安 ;林明杰, Chiang, Ying-Cheng;Chen, Chi-An;Chiang, Chun-Ju;Hsu, Tsui-Hsia;Lin, Ming-Chieh;You, San-Lin;Cheng, Wen-Fang;Lai, Mei-Shu   +1 more
core   +1 more source

Bilateral mucinous ovarian carcinoma in a young female with tumor weighing 41.1 kg

Journal of Family Medicine and Primary Care, 2022
Mucinous ovarian carcinoma is a less-prevalent subtype of epithelial tumors. We present a case of giant mucinous ovarian carcinoma weighing 41.1 kg in a 24-year-old Indian girl. Benign mucinous tumors have the potential to reach an enormous size but such
Kavita Khoiwal, Payal Kumari, Deepika Dhundi, Om Kumari, Anshu Gupta, Priyanka Gupta, Sonu Sama, Pankaj Sharma, Michael Anthony, Amrita Gaurav, Jaya Chaturvedi   +10 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Targeted anti-vascular therapies for ovarian cancer: current evidence [PDF]

, 2013
Ovarian cancer presents at advanced stage in around 75% of women, and despite improvements in treatments such as chemotherapy, the 5-year survival from the disease in women diagnosed between 1996 and 1999 in England and Wales was only 36%.
Mcneish, I., Gore, M., M Hall, Gore, M, C Gourley, Hall, M, Kaye, S, Gourley, C., Ledermann, J, McNeish, I, Jayson, G.; id_orcid, Gourley, C, G Jayson, Jayson, G., Kaye, S., Rustin, G, M Gore, J Ledermann, S Kaye, Perren, T, I McNeish, Hall, M., G Rustin, Rustin, G., Perren, T., T Perren, Jayson, G, Ledermann, J.   +27 more
core   +1 more source

High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers. [PDF]

PLoS ONE, 2013
OBJECTIVES:To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
Zhenhua Hu, Jian Gao, Danye Zhang, Qing Liu, Limei Yan, Lili Gao, Juanjuan Liu, Dawo Liu, Shulan Zhang, Bei Lin   +9 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker [PDF]

, 2010
The oncolytic adenovirus dl922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers.
Balkwill, F.R., Magdalena B Flak, Balkwill, FR, Chelala, C, McNeish, IA, Archibald, Kyra, Pirlo, K.J., Chelala, C., Iain A McNeish, Flak, M.B., Salako, MA, Pirlo, KJ, Katrina J Pirlo, Salako, M.A., Lockley, M, Connell, C.M., Mcneish, I.A., Lockley, M., Wheatley, S.P., Wheatley, SP, Flak, Magdalena B; id_orcid, Archibald, K, Archibald, K., Flak, MB, Michael A Salako, Michelle Lockley, Claude Chelala, McNeish, Iain A, Kyra Archibald, Frances R Balkwill, Pirlo, Katrina J, Lockley, Michelle, Connell, CM, Sally P Wheatley, Chelala, Claude, Balkwill, Frances R, Connell, Claire M, Claire M Connell, Salako, Michael A, Wheatley, Sally P   +39 more
core   +1 more source