Results 131 to 140 of about 235,116 (346)

Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review [PDF]

, 2018
Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with ...
Biankin, Andrew V., Khachigian, Levon M., Parish, Christopher R., Sheahan, Anjali V.   +3 more
core   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Advances in Early Detection of Pancreatic Cancer

Diagnostics, 2019
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. PDAC is the fourth leading cause of death in the United States and Japan based on epidemiological data. Early detection of PDAC is very important to improve the prognosis of PDAC.
Atsushi Kanno, Atsushi Masamune, Keiji Hanada, Masataka Kikuyama, Masayuki Kitano   +4 more
doaj   +1 more source

Needle Tract Seeding Following Transgastric Endoscopic Ultrasound-Fine Needle Aspiration for Pancreatic Tail Cancer: A Case Report. [PDF]

DEN Open
ABSTRACT We report the case of a 69‐year‐old man with a branch‐duct intraductal papillary mucinous neoplasm who underwent surveillance endoscopic ultrasound (EUS), which revealed a 15 mm hypoechoic mass in the pancreatic tail. Transgastric EUS‐guided fine needle aspiration (FNA) confirmed a diagnosis of resectable pancreatic ductal adenocarcinoma ...
Kuroda H, Iwashita T, Ohashi Y, Iwata S, Tezuka R, Uemura S, Murase K, Matsuhashi N, Miyazaki T, Shimizu M.   +9 more
europepmc   +2 more sources

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion [PDF]

, 2016
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer ...
Attwood, S, Auernheimer, V, Chronopoulos, A, Cortes, E, Del Rio Hernandez, AE, Fabry, B, Garcia, R, Ghassemi, S, Lachowski, D, Robinson, B, Sarper, M   +10 more
core   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types. [PDF]

, 2019
Cancer cell lines are a cornerstone of cancer research but previous studies have shown that not all cell lines are equal in their ability to model primary tumors.
Aran, D, Butte, AJ, Charalel, J, Chen, B, Goldstein, T, Sirota, M, van 't Veer, LJ, Wolf, DM, Yau, C, Yu, K   +9 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Pseudotumor pancreático

Revista do Colégio Brasileiro de Cirurgiões
The decrease in morbidity and mortality of pancreaticoduodenectomy in reference centers has increased the incidence of benign histopathologic diagnosis in cases where a pre-operative diagnosis of pancreatic ductal carcinoma was expected (9,2%).
Augusto Paulino Netto
doaj   +1 more source

Universality of a mesenchymal transition signature in invasive solid cancers [PDF]

, 2012
In this brief communication, additional computational validation is provided consistent with the unifying hypothesis that a shared biological mechanism of mesenchymal transition, reflected by a precise gene expression signature, may be present in all ...
Dimitris Anastassiou
core   +1 more source