Results 61 to 70 of about 83,751 (271)

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Papillary thyroid carcinoma

, 2010
One of the most important roles of thyroid fine needle aspiration (FNA) is the diagnosis of papillary thyroid carcinoma (PTC). PTC is the most common malignancy of the thyroid, representing approximately 60–80% of thyroid malignancies. PTC occurs more often in women, and although it can occur at any age, even in childhood, the peak incidence is in ...
Mostafa El-Feky, Frank Gaillard
openaire   +3 more sources

A five-gene signature predicts overall survival of patients with papillary renal cell carcinoma.

PLoS ONE, 2019
BACKGROUND:The present study aims to investigate the gene expression changes in papillary renal cell carcinoma(pRCC) and screen several genes and associated pathways of papillary renal cell carcinoma progression.
Ze Gao, Dong Zhang, Yi Duan, Lei Yan, Yidong Fan, Zhiqing Fang, Zhaoxu Liu   +6 more
doaj   +1 more source

Simultaneous occurrence of medullary and papillary thyroid microcarcinomas: a case series and review of the literature

Journal of Medical Case Reports, 2013
Introduction Papillary thyroid microcarcinoma has been demonstrated to present in association with medullary thyroid carcinoma, however, medullary thyroid carcinoma and papillary thyroid carcinoma represent rare entities.
Adnan Zaina, Arad Eldad, Dana James, Shendler Yaakov, Baron Elzbieta   +4 more
doaj   +1 more source

Papillary Urothelial Carcinoma [PDF]

Mayo Clinic Proceedings, 2021
Sounak Gupta, Roy Lipworth, Lance A. Mynderse   +2 more
openaire   +3 more sources

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Hereditary papillary renal cell carcinoma primarily diagnosed in a cervical lymph node: a case report of a 30-year-old woman with multiple metastases

BMC Urology, 2013
Background Papillary renal cell carcinoma is a rare cancer. Some cases can be attributed to individuals with hereditary renal cell carcinomas usually consisting of the clear cell subtype.
Behnes Carl Ludwig, Schlegel Christina, Shoukier Moneef, Magiera Isabella, Henschke Frank, Schwarz Alexander, Bremmer Felix, Loertzer Hagen   +7 more
doaj   +1 more source

Patch-based Carcinoma Detection on Confocal Laser Endomicroscopy Images -- A Cross-Site Robustness Assessment [PDF]

Proceedings of BIOIMAGING 2018, ISBN: 978-989-758-278-3, 2017
Deep learning technologies such as convolutional neural networks (CNN) provide powerful methods for image recognition and have recently been employed in the field of automated carcinoma detection in confocal laser endomicroscopy (CLE) images. CLE is a (sub-)surface microscopic imaging technique that reaches magnifications of up to 1000x and is thus ...
arxiv   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

Biochemical analysis of human breast tissues using FT-Raman spectroscopy [PDF]

, 2006
In this work we employ the Fourier Transform Raman Spectroscopy to study normal and tumoral human breast tissues, including several subtypes of cancers. We analyzed 194 Raman spectra from breast tissues that were separated into 9 groups according to their corresponding histopathological diagnosis.
arxiv   +1 more source