Results 111 to 120 of about 941,854 (310)

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R [PDF]

, 2013
Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the
Lucile Lefèvre, Ragazzon, Bruno, Constanze Hantel (280561), Guillaud-Bataille, Marine, Bruno Ragazzon (140444), Launay, Pierre, Stéphane Bonnet (280565), Marthe Rizk-Rabin (280575), Marine Guillaud-Bataille (9131), Karine Perlemoine, Lefèvre, Lucile, Sébastien Gaujoux (280559), Tissier, Frédérique, Hantel, Constanze, Frédérique Tissier (140448), Lucile Lefèvre (280570), Rizk-Rabin, Marthe, Karine Perlemoine (280567), Bertherat, Jérôme, Stéphane Bonnet, Bonnet, Stéphane, Sébastien Gaujoux, Perlemoine, Karine, Jérôme Bertherat, Bruno Ragazzon, Beuschlein, Felix, Marthe Rizk-Rabin, Frédérique Tissier, Pierre Launay (280563), Jérôme Bertherat (140471), Felix Beuschlein, Marine Guillaud-Bataille, Constanze Hantel, Felix Beuschlein (158361), Gaujoux, Sébastien, Pierre Launay   +35 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

KRAS Mutation in Small Cell Lung Carcinoma and Extrapulmonary Small Cell Cancer

Balkan Medical Journal, 2016
Background: Lung cancer is one of the most lethal cancers. It is mainly classified into 2 groups: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Extrapulmonary small cell carcinomas (EPSCC) are very rare.
Hilmi Kodaz, Ebru Taştekin, Bülent Erdoğan, İlhan Hacıbekiroğlu, Hilmi Tozkır, Hakan Gürkan, Esma Türkmen, Bora Demirkan, Sernaz Uzunoğlu, İrfan Çiçin   +9 more
doaj   +1 more source

Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck

, 2008
Introduction: Gefitinib, an orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces growth arrest in squamous cancer cell carcinoma of head and neck (SCCHN) cell lines mainly by blocking cells in G1 and preventing them ...
Romano, Carmela
core  

DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [PDF]

, 2014
Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis ...
Zain, R. B., Vincent-Chong, V. K., Tan, A. C., Khor, G. H., Thong, K. L., Omar, E., Froemming, G. R. A., Abraham, M. T., Tan, S. K.   +8 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Primary Hepatic Small-Cell Carcinoma Developed during Antiviral Treatment for Chronic Hepatitis B

Case Reports in Gastroenterology, 2015
Previously reported cases of primary hepatic small-cell carcinoma were all detected at progressed state with associated symptoms. Therefore, the natural course of primary hepatic small-cell carcinoma remains unknown. This case shows the natural course of
Suk Bae Kim
doaj   +1 more source

MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells

, 2011
Background: Esophageal squamous cell carcinoma (ESCC) is often diagnosed at later stages until they are incurable. MicroRNA (miR) is a small, non-coding RNA that negatively regulates gene expression mainly via translational repression.
Yamashita, S., Nakayama Toshiyuki, Matsushima Kayoko, Nagayasu, T., Inoue, N., Hidaka, S., Ohtsuru Akira, Yibin Kang, Hayashi, T., Hajime Isomoto, Masaki Kunizaki, Shigeru Kohno, Mitsutake Norisato, Hidaka Shigekazu, Ohtsuru, A., Takeshi Nagayasu, Naoki Inoue, Nakao Kazuhiko, Mitsutake, N., Nakashima Masahiro, Yamaguchi Naoyuki, Gregory Philip A, Kang Yibin, Matsushima, K., Isomoto Hajime, Ujifuku Kenta, Goodall, G., Kenta Ujifuku, Machida Haruhisa, Nakayama, T., Yamaguchi, N., Korpal Manav, Tomayoshi Hayashi, Kang, Y., Norisato Mitsutake, Philip A Gregory, Naoyuki Yamaguchi, Yamashita Shunichi, Haruhisa Machida, et al., Nagayasu Takeshi, Kohno, S., Machida, H., Nakashima, M., Manav Korpal, Shigekazu Hidaka, Kunizaki, M., Inoue Naoki, Toshiyuki Nakayama, Shunichi Yamashita, Akira Ohtsuru, Goodall Gregory J, Gregory J Goodall, Korpal, M., Kazuhiko Nakao, Isomoto, H., Hayashi Tomayoshi, Gregory, P., Ujifuku, K., Kunizaki Masaki, Kayoko Matsushima, Masahiro Nakashima, Kohno Shigeru   +62 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The role of the chemokine receptor CXCR4 in oral squamous cell carcinoma metastasis

, 2010
PhDOral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. The greatest cause of mortality and surgical morbidity is due to the common spread of tumour cells from the primary lesion to the lymph nodes of the neck. This pathway is
Collier, Jonathan Marc
core