Results 201 to 210 of about 949,312 (305)

Long-Term Response to Avelumab Maintenance Therapy and Durable Remission After Cessation in a Patient With Metastatic Urothelial Carcinoma of the Renal Pelvis: A Case Report. [PDF]

IJU Case Rep
Fujinami H, Hata S, Inoue T, Ando T, Shin T.   +4 more
europepmc   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

Glomerular disease associated with cancer: a case series of paraneoplastic nephrotic syndrome. [PDF]

Front Med (Lausanne)
Hu M, Ma Q, Wang L, Zhang T, Lin J, Yang X, Lv Z, Wang R.   +7 more
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Current Knowledge on UTUC Epidemiology in Poland Compared to Europe. [PDF]

Cancers (Basel)
Wnętrzak I, Wojciechowska U, Dobruch J, Czajkowski M, Sosnowski R, Krajewski W, Matuszewski M, Marczyński P, Didkowska JA.   +8 more
europepmc   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

The Emerging Role of B Cells and Tertiary Lymphoid Structures in Bladder Cancer. [PDF]

Curr Urol Rep
Penunuri A, Greenberg E, Phillips J, Katims AB.   +3 more
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

A master of disguise: A rare case of renal solitary fibrous tumour. [PDF]

Urol Case Rep
Saju PR, Sharoo Shaneej M, Raj R, De S, Aiyappan R, Aquil Faris SJ, Prudhvi Vasanth M.   +6 more
europepmc   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source