Results 21 to 30 of about 8,659 (227)

Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights. [PDF]

Front Oral Health, 2023
Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%–60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant
Scarini JF, de Lima-Souza RA, Lavareze L, Ribeiro de Assis MCF, Damas II, Altemani A, Egal ESA, Dos Santos JN, Bello IO, Mariano FV.   +9 more
europepmc   +2 more sources

Distinct copy number signatures between residual benign and transformed areas of carcinoma ex pleomorphic adenoma. [PDF]

Sci Rep
The mechanisms involved with the pathogenesis of carcinoma ex pleomorphic adenoma (CXPA) seem to be associated with the accumulation of molecular alterations in the pleomorphic adenoma (PA).
Scarini JF, Sabino WL, de Lima-Souza RA, Egal ESA, Tincani AJ, Gondak R, Kowalski LP, Krepischi ACV, Altemani A, Mariano FV.   +9 more
europepmc   +2 more sources

Influence of p16 Protein Immunostaining on Histopathological Features of Pleomorphic Adenoma and Carcinoma ex- Pleomorphic Adenoma. [PDF]

Asian Pac J Cancer Prev, 2023
The objective of this study was to evaluate the role of p16 in histologic characteristics and transition of Pleomorphic Adenoma (PA) to Carcinoma ex-PA (CxPA). So, 60 PA and 4 CxPA were histologic reviewed based on microscopic characteristics proposed by
Magalhaes IA, Barbosa KC, Costa GAJ, Oliveira Filho OV, Da Silva Junior JE, Gonzaga Silva LF, Juaçaba SF, Sousa FB, Barros Silva PG.   +8 more
europepmc   +2 more sources

Transoral robotic surgery for parapharyngeal carcinoma ex‐pleomorphic adenoma: A case report [PDF]

Cancer Reports, 2022
Background Carcinoma ex‐pleomorphic adenoma (Ca ex‐PA) comprises 0.5% of head and neck neoplasms. Transoral robotic surgery (TORS) is an approach being used to treat a variety of benign and malignant head and neck neoplasms.
Enrique Cadena‐Piñeros, Andrey Moreno‐Torres, Jessica Correa‐Marin, Mario A. Melo‐Uribe   +3 more
doaj   +2 more sources

Invasive ductal carcinoma ex pleomorphic adenoma of the lacrimal gland - a long term follow-up case

Human Pathology: Case Reports, 2017
We experienced a case of malignant orbital tumor in a 72-year-old Japanese man. He noticed protrusion of his left eye, and received resection of the left orbital tumor.
Naoko Nambu, Yoshitane Tsukamoto, Hiromi Tsuji, Takahiro Watanabe, Ryohei Shigehara, Masao Kakibuchi, Eiichi Morii, Seiichi Hirota   +7 more
doaj   +2 more sources

A Rare Case of Carcinoma Ex-pleomorphic Adenoma. [PDF]

J Microsc Ultrastruct, 2023
Abstract Pleomorphic adenoma is the most common benign salivary tumor involving the parotid gland. However, malignant transformation to carcinoma expleomorphic adenoma (CXPA) is an exceedingly rare occurrence. Malignant patterns reported with pleomorphic adenoma include CXPA, metastasizing pleomorphic adenoma, and carcinosarcoma. Firm mass in
Reddy R.
europepmc   +3 more sources

Carcinoma ex pleomorphic adenoma in an elderly patient: A case report and literature review

Oral and Maxillofacial Surgery Cases, 2022
Carcinoma ex pleomorphic adenoma (Ca ex PA) is a rare malignant tumor of salivary glands that originates in a primary (de novo) or recurrent pleomorphic adenoma. In the carcinoma component of Ca ex PA, many histological subtypes have been identified.
Atsuko Niki-Yonekawa, Yoshihiro Morita, Yukiko Kusuyama, Yoshio Ueno, Satoko Kishimoto, Nobuo Morita, Narikazu Uzawa   +6 more
doaj   +2 more sources

Trastuzumab Emtansine for the Treatment of HER-2 Positive Carcinoma Ex-pleomorphic Adenoma Metastatic to the Brain: A Case Report [PDF]

Frontiers in Oncology, 2018
Background: Carcinoma Ex-pleomorphic adenoma is a malignant transformation of the common benign neoplasm of the salivary glands, “pleomorphic adenoma.” Only two cases were ever reported with brain metastases, with absence of good evidence guiding ...
Ihab Hassanieh, Ihab Hassanieh, Lara Hilal, Lara Hilal, Karine A. Al Feghali, Karine A. Al Feghali, Ibrahim Khalifeh, Bassem Youssef, Bassem Youssef   +8 more
doaj   +3 more sources

Progressivity analysis of pleomorphic adenoma toward carcinoma ex pleomorphic adenoma

Dental Journal, 2022
Background: Pleomorphic adenoma (PA) is a benign salivary gland tumour with high incidence and recurrence after treatment. It may recur with the same appearance or develop toward malignancy, namely as carcinoma ex pleomorphic adenoma (CXPA).
Mei Syafriadi, Dina Zakiyatul Ummah, Aisyah Izzatul Muna, Maria Evata Krismawati Surya   +3 more
doaj   +4 more sources

Peculiar nuclear atypia associated with MDM2 gene amplification in carcinoma ex‐pleomorphic adenoma harbouring an alteration of HMGA2 [PDF]

Histopathology
Salivary gland neoplasms (SGN) exhibiting the HMGA2::WIF1 fusion are recognized by their resemblance to histology found in canalicular adenoma. Recently, ~20% of cases among 28 HMGA2::WIF1‐rearranged‐SGN showed malignancy and adverse outcomes (recurrence,
Ziyad Alsugair, M. Fieux, Françoise Descôtes, Jonathan Lopez, Carolle Cordonnier, Juliette Russel, Anne Champagnac, Daniel Pissaloux, Philippe Céruse, Pierre Philouze, Nazim Benzerdjeb   +10 more
openalex   +2 more sources