Results 241 to 250 of about 2,761,482 (311)

The estrobolome: Estrogen‐metabolizing pathways of the gut microbiome and their relation to breast cancer

International Journal of Cancer, EarlyView.
Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder, Amee R. Manges, Rachel A. Murphy   +2 more
wiley   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, EarlyView.
What's New? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

The TESTBREAST journey: Revisiting the importance of early detection by frequent screening of women at high risk of breast cancer

International Journal of Cancer, EarlyView.
What's New? Women who are at high risk of breast cancer (BC), either because of a BRCA1/2 mutation or family history, require more aggressive screening. Here, the authors report on the clinical characteristics of the high‐risk women who developed BC during the TESTBREAST study. Of the 1108 participants, 124 (16.5%) developed breast cancer. Their median
Layla Andour, Sophie C. Hagenaars, Kiki Vangangelt, Janneke Aalberts, Valerie Rebattu, Dorien M. A. Berends van der Meer, Elma Meershoek‐Klein Kranenbarg, Katja N. Gaarenstroom, Christi J. van Asperen, Rob A. E. M. Tollenaar, Wilma E. Mesker, on behalf of the TESTBREAST study team, J. Aalberts, T. M. A. Berends‐van der Meer, S. C. Hagenaars, L. Andour, W.E. Mesker, R. A. E. M Tollenaar, W. M. Meershoek‐Klein Kranenbarg, K. N. Gaarenstroom, C. M. R. Haekens, K. B. M. I. Keymeulen, J. Remmelzwaal, M. Piek‐den Hartog, E. J. T. Rutgers, C. Drukker, C. Lemstra, A. Prozee, J. de Vries, A. Stam, C. Bandel, I. Meijer, A. E. Dassen, S. Makineli, E. E. van Oers‐Hazelzet, A. J. Witkamp, K. E. Schenk, W. van der Eijk, M. B. E. Menke‐Pluijmers, J. de Droog‐Laane, B. A. Kortmann   +40 more
wiley   +1 more source

Whole‐genome sequencing of 1,083 HPV45 cases and controls identifies genetic variants associated with glandular cervical lesions

International Journal of Cancer, EarlyView.
What's New? Little is known about how genetic variation in human papillomavirus type 45 (HPV45) influences its ability to cause cancer. Here, the authors conducted the largest whole‐genome sequencing study to date of HPV45, looking for associations between viral genetic variation and precancer or cancer risk.
Aimee J. Koestler, Chase W. Nelson, Meredith Yeager, Zigui Chen, Sambit K. Mishra, Laurie Burdett, Michael Dean, Elizabeth Suh‐Burgmann, Thomas Lorey, Gary M. Clifford, Nicolas Wentzensen, Philip E. Castle, Mark Schiffman, Robert D. Burk, Lisa Mirabello   +14 more
wiley   +1 more source

Improved cervical screening using HPV type restriction and cycle threshold limit setting with the AmpFire assay: A prospective screening cohort of women with and without HIV in Botswana

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of this study was to evaluate the performance of HPV type restriction and cycle threshold (Ct)‐limit setting to optimize detection of cervical intraepithelial neoplasia (CIN) with primary HPV testing. Methods Baseline cervical screening at time of entry into a prospective longitudinal cohort of women with and without HIV was ...
Rebecca Luckett, Doreen Ramogola‐Masire, Sikhulile Moyo, Annika Gompers, Anna Modest, Natasha Moraka, Thanolo Kashamba, Leabaneng Tawe, Farzad Noubary, Louise Kuhn, Surbhi Grover, Scott Dryden‐Peterson, Greta Dreyer, Joseph Makhema, Matthys H. Botha, Michele R. Hacker, Roger Shapiro   +16 more
wiley   +1 more source

Supernumerary chromosome 1 in interphase nuclei of atypical germ cells in paraffin-embedded human seminiferous tubules [PDF]

, 1989
Bannwart, F., Cremer, Thomas, Emmerich, Patricia, Hofmann, M. C., Walt, H.   +4 more
core  

Topical imiquimod and in situ vulvar melanoma: A promising therapy?

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives Vulvar melanoma is a rare type of cancer that affects mainly postmenopausal women. There are no established protocols for the treatment of vulvar melanoma. From data extrapolated from the literature on cutaneous melanoma, surgical excision remains the best option for the resectable disease.
Francesca Pepe, Flavia Silvestri, Eleonora Petra Preti, Anna Daniela Iacobone, Gianluigi Radici, Sabina Vaccari, Paola Queirolo, Giulio Tosti   +7 more
wiley   +1 more source

HPV vaccination coverage rate in women undergoing conization for cervical intraepithelial neoplasia in Spain: The COVAR study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Females subjected to cervical excisional therapy (conization) due to high‐grade squamous intraepithelial lesions/cervical intraepithelial neoplasia HSIL/CIN have a higher risk of developing cervical lesions compared to the general population. Research suggests that HPV vaccination may reduce post‐treatment HSIL/CIN risk.
Aureli Torné Blade, María del Mar Ramírez Mena, Jesús de la Fuente Valero, Raquel Oliva Sánchez, José Quílez Conde, Manuela Sala Ferichola, Jesús Osuna Pérez, Antonio Rivera, Bruno Herrera Bruch, Gonzalo Fernández, Noelia López, María Villarejo, Marta del Pino Saladrigues   +12 more
wiley   +1 more source

Barriers in the prevention and early detection of human papillomavirus in Latin America

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the individual, social, cultural, health system, and structural barriers related to the human papillomavirus (HPV) in women from eight Latin American countries. Methods A prospective, relational, and analytical study was conducted from July to August 2024 in women from eight Latin American countries: Argentina, Colombia ...
Leopoldo Santiago Sanabria, Viviana Angélica Laverde Cardona, Yotin Ramón Pérez D, Fabrizio Abreu, María Luisina Cicerchia, Camila Cajelli, Martín de Jesús Inurreta Díaz, Mirtha Jimena Vásquez Medina, Karina Auxiliadora Amador, Gery Rosmary Ruiz Carillo   +9 more
wiley   +1 more source

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The global existence and numerical method for the free boundary problem of ductal carcinoma in situ

Mathematical methods in the applied sciences, 2022
In this paper, a free boundary problem related to the ductal carcinoma in situ (DCIS) model is under studied. We establish the global existence and uniqueness of the solution for the model with the non‐symmetric free boundaries.
Dan Liu, Keji Liu, Xinyi Xu, Jianfeng Yu
semanticscholar   +1 more source