Results 31 to 40 of about 36,426 (246)
Disregarded effect of biological fluids in siRNA delivery : human ascites fluid severely restricts cellular uptake of nanoparticles [PDF]
, 2015 Small interfering RNA (siRNA) offers a great potential for the treatment of various diseases and disorders. Nevertheless, inefficient in vivo siRNA delivery hampers its translation into the clinic.
Braeckmans, Kevin +5 more
core +2 more sources
Drug Delivery, 2017 The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration
Margo Steuperaert +6 more
doaj +1 more source
Cytoreduction and HIPEC in the treatment of "unconventional" secondary peritoneal carcinomatosis [PDF]
, 2015 BACKGROUND: Peritoneal metastasis (PM) is considered a terminal and incurable disease. In the last 30 years, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) radically changed the therapeutic approach for these patients ...
Accarpio, Fabio +8 more
core +2 more sources
Current Oncology, 2023 Cytoreductive surgery (CRS) represents the cornerstone of surgical management for peritoneal carcinomatosis (PC) and involves peritonectomy procedures aimed at complete peritoneal tumour resection.
Megan Fallows +3 more
doaj +1 more source
Targeting the tumor microenvironment in colorectal peritoneal metastases
, 2020 Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim +4 more
core +1 more source
Preliminary Experience and Morbidity Analysis of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS/Hipec) from a Tertiary Cancer Center in India [PDF]
Journal of Clinical and Diagnostic Research, 2015 Background: Peritoneal carcinomatosis (PC) can arise directly from peritoneum (primary) or from regional spread of gastrointestinal and gynecological malignancies. It is often considered a terminal event.
Naveen Padmanabhan +4 more
doaj +1 more source
Exploring the HYDRAtion method for loading siRNA on liposomes : the interplay between stability and biological activity in human undiluted ascites fluid [PDF]
, 2016 Delivery of small interfering RNA (siRNA) is recently gaining tremendous attention for the treatment of ovarian cancer. The present study investigated the potential of different liposomal formulations composed of (2,3-dioleoyloxy-propyl)trimethylammonium
Braeckmans, Kevin +4 more
core +2 more sources
Journal of Medical Sciences, 2016 We report three cases of Krukenberg tumor (KT): two were synchronous and one metachronous. At presentation, the first synchronous KT patient had a palpable umbilical mass, the second had a perforated peptic ulcer, and the metachronous KT patient had an ...
Li-Yung Chen +3 more
doaj +1 more source
Journal of Community Hospital Internal Medicine Perspectives, 2020 Gastric cancer is the fifth most common cancer in the world and the third leading cause of cancer-related deaths. Signet-ring cell type is the most malicious subtype. We report a case of advanced stage gastric adenocarcinoma case post-radical gastrectomy
Yuting Huang +3 more
doaj +1 more source
Unravelling Peritoneal Carcinomatosis Using Cross-Sectional Imaging Modalities
Diagnostics, 2023 Peritoneal carcinomatosis (PC) refers to malignant epithelial cells that spread to the peritoneum, principally from abdominal malignancies. Until recently, PC prognosis has been considered ill-fated, with palliative therapies serving as the only ...
Ana Veron Sanchez +9 more
doaj +1 more source