Results 241 to 250 of about 4,738,170 (353)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Silent progression: cardiac amyloidosis unmasking IgG lambda myeloma in an elderly patient. [PDF]

Egypt Heart J
Touiti S, Bouali M, El Bahri L, Asfalou I, Lakhal Z, Benyass A.   +5 more
europepmc   +1 more source

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype

Advanced Healthcare Materials, EarlyView.
Replicating tissue‐specific extracellular matrix is crucial for understanding its role in disease. This work demonstrates independent control over stiffness, composition and 3D collagen architecture using hybrid scaffolds: patterned collagen perfused with defined hydrogels.
Xinyuan Song, Samantha C. Mitchell, Abbie N. Smart, William Hardiman, Daniel V. Bax, Ceri E. Staley, Catherine Probert, Pamela Collier, Marian Meakin, Alison A. Ritchie, Tania Mendonca, Amanda J. Wright, Victoria James, Anna M. Grabowska, Catherine L. R. Merry, Serena M. Best, Ruth E. Cameron, Jennifer C. Ashworth   +17 more
wiley   +1 more source

Unraveling SUDEP: Mechanisms of Seizure-Induced Cardiac and Respiratory Impairment. [PDF]

Epilepsy Curr
Wenker IC, Gehlbach BK, Isom LL, Dlouhy BJ, Auerbach DS, Maguire JL, Boychuk CR.   +6 more
europepmc   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Pannexins in the heart: cell-specific expression and contributions to disease. [PDF]

Cell Tissue Res
Renton MC, Sedovy MW, Reynolds A, Hoch A, Roberts K, Sarmiento R, Toler C, Johnstone SR.   +7 more
europepmc   +1 more source

Machine Learning of Cardiac Anatomy and the Risk of New-Onset Atrial Fibrillation After TAVR

Mark Brahier, Shwetha Kochi, Julia Huang, Emma Piliponis, Andrew Smith, Adam Johnson, Suraya Poian, Musa Abdulkareem, Xiaoyang Ma, Colin O. Wu, Jonathan P. Piccini, Steffen E. Petersen, Jose D. Vargas   +12 more
openalex   +2 more sources

Incorporating Comorbidity Within Risk Adjustment for UK Pediatric Cardiac Surgery

, 2017
Kate Brown, Libby Rogers, David J. Barron, Victor Tsang, David Anderson, Shane M. Tibby, Thomas Witter, John Stickley, Sonya Crowe, Kate English, Rodney C. G. Franklin, Christina Pagel   +11 more
openalex   +1 more source

Characterizing cardiac phenotype in Friedreich's ataxia: The CARFA study

, 2021
L. Legrand, Jonathan W. Weinsaft, Françoise Pousset, Claire Ewenczyk, Perrine Charles, Stéphane Hatem, Anna Heinzmann, Marie Biet, Alexandra Dürr, Alban Redheuil   +9 more
openalex   +2 more sources

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source