Results 21 to 30 of about 4,670,891 (357)

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest

New England Journal of Medicine, 2021
BACKGROUND: Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS: In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma
J. Dankiewicz, T. Cronberg, G. Lilja, J. Jakobsen, Helena Levin, S. Ullén, C. Rylander, M. Wise, M. Oddo, A. Cariou, J. Bělohlávek, J. Hovdenes, M. Saxena, H. Kirkegaard, P. Young, P. Pelosi, C. Storm, F. Taccone, M. Joannidis, C. Callaway, G. Eastwood, Matt Morgan, P. Nordberg, D. Erlinge, A. Nichol, M. Chew, J. Hollenberg, M. Thomas, J. Bewley, K. Sweet, A. Grejs, S. Christensen, M. Haenggi, Anja Levis, A. Lundin, J. Düring, S. Schmidbauer, T. Keeble, G. Karamasis, C. Schrag, Edith Faessler, O. Šmíd, M. Otáhal, M. Maggiorini, P. D. Wendel Garcia, P. Jaubert, J. Cole, M. Solař, O. Borgquist, C. Leithner, Samia Abed-Maillard, L. Navarra, M. Annborn, J. Undén, I. Brunetti, Akil Awad, Peter Mcguigan, Roy Bjørkholt Olsen, T. Cassina, P. Vignon, Halvor Langeland, T. Lange, H. Friberg, N. Nielsen   +63 more
semanticscholar   +1 more source

The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology

Frontiers in Immunology, 2023
Cardiac and pericardial macrophages contribute to both homeostatic and pathophysiological processes. Recent advances have identified a vast repertoire of these macrophage populations in and around the heart - broadly categorized into a CCR2+/CCR2 ...
Carmina Albertine Isidoro, Carmina Albertine Isidoro, Justin F. Deniset, Justin F. Deniset, Justin F. Deniset   +4 more
doaj   +1 more source

Cell augmentation strategies for cardiac stem cell therapies

Stem Cells Translational Medicine, 2021
Myocardial infarction (MI) has been the primary cause of death in developed countries, resulting in a major psychological and financial burden for society. Current treatments for acute MI are directed toward rapid restoration of perfusion to limit damage
Raquel Cruz‐Samperio, Millie Jordan, Adam Perriman   +2 more
doaj   +1 more source

Does the revised cardiac risk index predict cardiac complications following elective lung resection? [PDF]

, 2013
Background: Revised Cardiac Risk Index (RCRI) score and Thoracic Revised Cardiac Risk Index (ThRCRI) score were developed to predict the risks of postoperative major cardiac complications in generic surgical population and thoracic surgery respectively.
A Bobbio, A Brunelli, A Brunelli, A Brunelli, Amy Kerr, Andrea Marshall, AS Detsky, Babu Naidu, CA Polanczyk, CD Parmar, D Amar, DJ Bertges, DW Hosmer, E Lim, Ehab Bishay, HC Fernando, JP Mathew, L Goldman, LA Fleisher, Maninder Kalkat, MK Ferguson, MK Ford, Pala Rajesh, Richard Steyn, Robin Wotton, TH Lee, V Fuster, WD Neary   +27 more
core   +2 more sources

Thymoquinone Prevents Myocardial and Perivascular Fibrosis Induced by Chronic Lipopolysaccharide Exposure in Male Rats - Thymoquinone and Cardiac Fibrosis -

Journal of Pharmacopuncture, 2018
Objectives: Thymoquinone (TQ) is one of the active ingredients of herbal plants such as Nigella sativa L. (NS) which has beneficial effects on the body. The beneficial effects of TQ on the cardiovascular system have reported.
Fereshteh Asgharzadeh, Rahimeh Bargi, Farimah Beheshti, Mahmoud Hosseini, Mehdi Farzadnia, Majid Khazaei   +5 more
doaj   +1 more source

Remote Cardiac Safety Monitoring through the Lens of the FDA Biomarker Qualification Evidentiary Criteria Framework: A Case Study Analysis

Digital Biomarkers, 2021
Clinical safety findings remain one of the reasons for attrition of drug candidates during clinical development. Cardiovascular liabilities are not consistently detected in early-stage clinical trials and often become apparent when drugs are administered
Elena S. Izmailova, William A. Wood, Qi Liu, Vadim Zipunnikov, Daniel Bloomfield, Jason Homsy, Steven C. Hoffmann, John A. Wagner, Joseph P. Menetski   +8 more
doaj   +1 more source

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment [PDF]

, 2018
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications.
Ball, V, Betts, C A, Gait, M J, Godfrey, C, Hammond, S M, Healicon, R, Manzano, R, McClorey, G, Merritt, T M, Muses, S, O'Donovan, L, Tyler, D, Wells, D J, Wells, K E, Westering, T, Wood, M J   +15 more
core   +2 more sources

Deep Learning Techniques for Automatic MRI Cardiac Multi-Structures Segmentation and Diagnosis: Is the Problem Solved?

IEEE Transactions on Medical Imaging, 2018
Delineation of the left ventricular cavity, myocardium, and right ventricle from cardiac magnetic resonance images (multi-slice 2-D cine MRI) is a common clinical task to establish diagnosis.
O. Bernard, A. Lalande, Clément Zotti, F. Cervenansky, Xin Yang, P. Heng, Irem Cetin, K. Lekadir, O. Camara, M. G. gonzález Ballester, G. Sanromá, S. Napel, Steffen Erhard Petersen, G. Tziritas, E. Grinias, Mahendra Khened, V. Kollerathu, Ganapathy Krishnamurthi, Marc-Michel Rohé, X. Pennec, Maxime Sermesant, Fabian Isensee, Paul F. Jäger, Klaus Hermann Maier-Hein, Peter M. Full, I. Wolf, S. Engelhardt, Christian F. Baumgartner, Lisa M. Koch, J. Wolterink, I. Išgum, Yeonggul Jang, Yoonmi Hong, Jay Patravali, Shubham Jain, O. Humbert, Pierre-Marc Jodoin   +36 more
semanticscholar   +1 more source

Epidemiology of Musculoskeletal Injury during Racing on New Zealand Racetracks 2005–2011

Animals, 2017
The objective of the study was to determine the incidence of veterinary events that resulted in a horse failing to finish a race and identify risk factors for musculoskeletal injury (MSI) during a race. Data were obtained on Thoroughbred flat race starts
Charlotte Bolwell, Chris Rogers, Erica Gee, Wayne McIlwraith   +3 more
doaj   +1 more source

The effect of illegal drug screening results and chronic drug use on perioperative complications in trauma

Journal of Emergencies, Trauma and Shock, 2020
Context: Illegal drug use and need for surgery are common in trauma. This allows examination of the effects of perioperative drug use. Aim: The aim was to study the effects of illegal drug use on perioperative complications in trauma. Setting and Design:
John T Culhane, Carl A Freeman
doaj   +1 more source