Results 311 to 320 of about 1,299,020 (330)

Cardiac amyloidosis

Expert Review of Cardiovascular Therapy, 2014
Amyloidosis is a condition characterized by the extracellular deposition of insoluble fibrillar protein in tissues and various organs including the heart. This review summarizes the clinical manifestations and diagnostic treatment approaches for cardiac amyloidosis.
Syed Wamique, Yusuf, Amirreza, Solhpour, Jose, Banchs, Juan C, Lopez-Mattei, Jean-Bernard, Durand, Cezar, Iliescu, Saamir A, Hassan, Muzaffar H, Qazilbash   +7 more
openaire   +2 more sources

Amyloidosis with cardiac involvement [PDF]

Postgraduate Medical Journal, 2010
A previously well man in his 70s presented with a 2 month history of progressive dyspnoea, peripheral oedema, and purpuric rash affecting his legs. On examination, he was hypoxic, had ascites, bipedal oedema, and purpura on his legs. Bloods revealed a normocytic anaemia, renal failure, and hypoalbuminaemia.
Shahid Aziz, Adrian S W Yong
openaire   +2 more sources

The genetics of cardiac amyloidosis

Heart Failure Reviews, 2021
Heritable cardiac amyloidosis (CA) is an underrecognized cause of morbidity and mortality in the USA. It results from the accumulation of the misfolded protein transthyretin within the myocardium, resulting in amyloid transthyretin-associated cardiomyopathy (ATTR-CM). Over 150 different pathologic point mutations within the transthyretin gene have been
Scott Arno, Jennifer Cowger
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Echocardiography in cardiac amyloidosis

Heart Failure Reviews, 2015
Echocardiography is the most widely used noninvasive test in patients with heart failure or abnormal cardiac findings on examination. Patients with amyloidosis may have significant cardiac abnormalities, several of which are highly suggestive of the disease. This article reviews echocardiographic features found in cardiac amyloidosis.
Rodney H. Falk, Candida Cristina Quarta, Candida Cristina Quarta   +2 more
openaire   +3 more sources

Pathophysiology of Cardiac Amyloidosis

Heart Failure Clinics
Amyloidosis refers to a heterogeneous group of disorders sharing common pathophysiological mechanisms characterized by the extracellular accumulation of fibrillar deposits consisting of the aggregation of misfolded proteins. Cardiac amyloidosis (CA), usually caused by deposition of misfolded transthyretin or immunoglobulin light chains, is an ...
Morfino, Paolo, Aimo, Alberto, Franzini, Maria, Vergaro, Giuseppe, Castiglione, Vincenzo, Panichella, Giorgia, Limongelli, Giuseppe, Emdin, Michele   +7 more
openaire   +3 more sources

Keys to early diagnosis of cardiac amyloidosis: red flags from clinical, laboratory and imaging findings

European Journal of Preventive Cardiology, 2020
Cardiac involvement in systemic amyloidosis, due either to immunoglobulin light-chain or transthyretin amyloidosis, influences clinical presentation and is a strong predictor of unfavourable outcome. Until recently considered as a rare, incurable disease,
G. Vergaro, A. Aimo, A. Barison, D. Genovesi, G. Buda, C. Passino, M. Emdin   +6 more
semanticscholar   +1 more source

Cardiac transthyretin amyloidosis

Heart, 2012
Cardiac amyloidosis of transthyretin fibril protein (ATTR) type is an infiltrative cardiomyopathy characterised by ventricular wall thickening and diastolic heart failure. Increased access to cardiovascular magnetic resonance imaging has led to a marked increase in referrals to our centre of Caucasian patients with wild-type ATTR (senile systemic ...
Jason Dungu, Lisa J. Anderson, Philip N. Hawkins, Carol J. Whelan   +3 more
openaire   +2 more sources

Primary cardiac amyloidosis

American Heart Journal, 1953
Abstract Two cases of amyloidosis limited to the heart and one case of amyloidosis involving the heart and lungs are reported. All three patients were men in, or close to, the ninth decade of life. In all three cases auricular fibrillation and congestive failure were present. The literature is reviewed and a distinction drawn between systemic primary
William D. Angle, Thomas G. Morrione, Alexander I. Thomashow   +2 more
openaire   +3 more sources

Transthyretin Cardiac Amyloidosis

Current Cardiology Reports, 2017
Transthyretin (TTR)-related cardiac amyloidosis is a progressive infiltrative cardiomyopathy that mimics hypertensive, hypertrophic heart disease and may go undiagnosed. Transthyretin-derived amyloidosis accounts for 18% of all cases of cardiac amyloidosis.
Anit K. Mankad, Keyur B. Shah
openaire   +3 more sources

Serum amyloidosis: a cardiac amyloidosis

European Heart Journal - Cardiovascular Imaging, 2023
Jeremy A Slivnick, Varun Subashchandran, Nitasha Sarswat, Amit R Patel   +3 more
openaire   +2 more sources