Results 111 to 120 of about 1,876,979 (380)

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest [PDF]

, 2014
Introduction: Early prognostication after successful cardiopulmonary resuscitation is difficult, and there is a need for novel methods to estimate the extent of brain injury and predict outcome.
Patrik Gilje, Olof Gidlöf, Malin Rundgren, Tobias Cronberg, Mariam Al-Mashat, Björn Olde, Hans Friberg, David Erlinge   +7 more
core   +1 more source

Targeted temperature management at 33°C versus 36°C after cardiac arrest.

New England Journal of Medicine, 2013
BACKGROUND Unconscious survivors of out-of-hospital cardiac arrest have a high risk of death or poor neurologic function. Therapeutic hypothermia is recommended by international guidelines, but the supporting evidence is limited, and the target ...
N. Nielsen, J. Wetterslev, T. Cronberg, D. Erlinge, Y. Gasche, C. Hassager, J. Horn, J. Hovdenes, J. Kjaergaard, M. Kuiper, T. Pellis, P. Stammet, M. Wanscher, M. Wise, A. Åneman, N. Al-Subaie, S. Boesgaard, J. Bro-Jeppesen, I. Brunetti, J. Bugge, C. Hingston, N. Juffermans, M. Koopmans, L. Køber, J. Langørgen, G. Lilja, J. Møller, M. Rundgren, C. Rylander, O. Šmíd, C. Werer, P. Winkel, H. Friberg   +32 more
semanticscholar   +1 more source

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria   +4 more
wiley   +1 more source

Out-of-hospital cardiac arrest in Hong Kong: a territory-wide study [PDF]

, 2017
INTRODUCTION: Out-of-hospital cardiac arrest is a global health care problem. Like other cities in the world, Hong Kong faces the impact of such events.
Fan, KL, Leung, LP, Siu, YC
core   +1 more source

Miniaturized Devices for On‐the‐Spot Generation of Small‐Diameter Vascular Grafts

Advanced Materials Technologies, EarlyView.
An intracorporeal extrusion device is developed for on‐the‐spot generation of vascular grafts with tunable diameters spanning from 1 to 6 mm. The device uses biomimetic polymers and light, to promptly obtaining biocompatible and high‐burst pressure‐resistant grafts.
Deyanira Hernandez‐Sanchez, Maxime‐Emmanuel Comtois‐Bona, Antony El‐Khoury, Sergio David Garcia Schejtman, Aidan Macadam, Juan‐David Figueroa‐Alegria, Jesus M. Calderon‐Torres, Irene Guzmán‐Soto, Marc Ruel, Erik J. Suuronen, Marcelo Muñoz, Emilio I. Alarcon   +11 more
wiley   +1 more source

Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association.

Circulation, 2019
Significant improvements have been achieved in cardiac arrest resuscitation and postarrest resuscitation care, but mortality remains high. Most of the poor outcomes and deaths of cardiac arrest survivors have been attributed to widespread brain injury ...
R. Geocadin, C. Callaway, E. Fink, Eyal Golan, D. Greer, N. Ko, E. Lang, D. Licht, B. Marino, N. D. McNair, M. Peberdy, S. Perman, D. Sims, J. Soar, C. Sandroni   +14 more
semanticscholar   +1 more source

Multifunctional Fibrous Mats: Stretchable, Conductive, and Hydrophilic Platforms for Wearable Electronics

Advanced Materials Technologies, EarlyView.
A hydrophilic, stretchable, nonwoven electrospun fiber mat targeted to be applied in long‐term bioelectronic devices. By incorporating amphiphilic polyethylene glycol block copolymers in a polydimethylsiloxane matrix, the material develops stable hydrophilicity, enhanced breathability, as well as enhanced adhesion to cells.
Joab S. Dorsainvil, Jafar Batayneh, Maya McDonald, Natalie Pachter, Serena Patel, Dana Manashirov, Tracy Hookway, Ahyeon Koh   +7 more
wiley   +1 more source

School District Assessment for Sudden Cardiac Arrest Preparation [PDF]

, 2014
A literature review on pediatric sudden cardiac arrest (SCA) suggests that school nurses nationwide are well supported in their responsibilities to manage SCA in school children, despite budget and equipment challenges.
Dahlen, Paula
core