Results 71 to 80 of about 1,876,979 (380)

Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia [PDF]

, 2006
Growth arrest and DNA damage protein 34 (GADD34) is a multifunctional protein upregulated in response to cellular stress and is believed to mediate DNA repair and restore protein synthesis. In the present study we have examined GADD34 immunoreactivity in
Brown, C. McCabe, Chou, Doutheil, E. Morton, F. White, Fornace, Hannan, Harland, He, Hollander, Horman, I.M. Macrae, Imai, S.M. Brown, White   +15 more
core   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Prehospital emergency medicine research by additional teams on scene – Concepts and lessons learned

Resuscitation Plus, 2023
While the initial minutes of acute emergencies significantly influence clinical outcomes, prehospital research often receives inadequate attention due to several challenges.
Matthias Mueller, Heidrun Losert, Fritz Sterz, Georg Gelbenegger, Michael Girsa, Mathias Gatterbauer, Andreas Zajicek, Daniel Grassmann, Mario Krammel, Michael Holzer, Thomas Uray, Sebastian Schnaubelt   +11 more
doaj  

The Automatic External Cardioverter-Defibrillator [PDF]

, 2004
In-hospital cardiac arrest remains a major problem but new technologies allowing fully automatic external defibrillation are available. These technologies allow the concept of “external therapeutic monitoring” of lethal arrhythmias.
Barón-Esquivias, Gonzalo, Martínez-Rubio, Antoni   +1 more
core   +2 more sources

Dual‐Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing

Advanced Functional Materials, EarlyView.
CD105‐LNPs and PS‐LNPs can deliver α‐lipoic acid to bone marrow mesenchymal stem cells and bone marrow‐derived macrophages, reversing high glucose‐induced oxidative stress while enhancing osteogenesis and M2 polarization. Integrating both nanoparticles into glucose‐responsive hyaluronic acid hydrogel forms DLNPs@HA hydrogel, which accelerates diabetic ...
Yanzhi Zhao, Weixian Hu, Shengming Zhang, Yuheng Liao, Kangkang Zha, Chenyan Yu, Zhenhe Zhang, Wenqian Zhang, Bobin Mi, Faqi Cao, Guohui Liu, Wu Zhou   +11 more
wiley   +1 more source

Factors associated with post-arrest withdrawal of life-sustaining therapy. [PDF]

, 2017
INTRODUCTION: Most successfully resuscitated cardiac arrest patients do not survive to hospital discharge. Many have withdrawal of life sustaining therapy (WLST) as a result of the perception of poor neurologic prognosis.
Abella, Benjamin S., Gaieski, David F., Grossestreuer, Anne V., Haukoos, Jason S., Ikeda, Daniel J., Moskowitz, Ari, Perman, Sarah M., Wiebe, Douglas J.   +7 more
core   +1 more source

Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest : The PRINCESS Randomized Clinical Trial [PDF]

, 2019
© 2019 American Medical Association. All rights reserved.Importance: Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest.
Abella, Abou-Chebl, Adeline Higuet, Anatolij Truhlar, Bernard, Bernard, Busch, Callaway, Caroline Busche, Castrén, Che, David Konrad, Debaty, Didier Desruelles, Emelie Dillenbeck, Fabio Silvio Taccone, Fernando Rosell Ortiz, Francisco Carmona Jiménes, Froehler, Hans-Jörg Busch, Hypothermia after Cardiac Arrest Study Group, Jacob Hollenberg, Jacques Creteur, Jean-Louis Vincent, Jennett, Jerome Cuny, Johan Peterson, Julia Williams, Kim, Leif Svensson, Martin Jonsson, Mattias Ringh, Nick Vermeersch, Nielsen, Nolan, Nolan, Nordberg, Patrick Goldstein, Per Nordberg, Perkins, Scolletta, Sune Forsberg, Yu, Zhang   +43 more
core   +3 more sources

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

Cardiac arrest during gamete release in chum salmon regulated by the parasympathetic nerve system. [PDF]

PLoS ONE, 2009
Cardiac arrest caused by startling stimuli, such as visual and vibration stimuli, has been reported in some animals and could be considered as an extraordinary case of bradycardia and defined as reversible missed heart beats.
Yuya Makiguchi, Shinya Nagata, Takahito Kojima, Masaki Ichimura, Yoshifumi Konno, Hideki Murata, Hiroshi Ueda   +6 more
doaj   +1 more source

Teaching approach of ACLS in cardiac arrest with pregnancy

Medicine Science, 2021
Cardiac arrest is the abrupt loss of heart function in a person. Cardiac arrest can be lifesaving and it is important to understand the causes of maternal mortality to have an understanding of the unique pathogenic factors that may have precipitated the ...
Adel Hamed Elbaih, Anas Yahia Alkhalaileh, Ossama Ashour Haikal   +2 more
doaj   +1 more source