Results 141 to 150 of about 154,358 (318)

Cardiac Arrhythmias Induced by Minimal Doses of Epinephrine in Cyclopropane-Anesthetized Dogs [PDF]

, 1960
PETER B. DRESEL, Keith L. MacCannell, Mark Nickerson   +2 more
openalex   +1 more source

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

ChemMedChem, EarlyView.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés, Eli Fernández‐de Gortari, Rodrigo Aguayo‐Ortiz, Jaroslava Šeflová, Adam Ard, Martin Clasby, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +7 more
wiley   +1 more source

Finding "Good Views" of Electrocardiogram Signals for Inferring Abnormalities in Cardiac Condition [PDF]

arXiv
Electrocardiograms (ECGs) are an established technique to screen for abnormal cardiac signals. Recent work has established that it is possible to detect arrhythmia directly from the ECG signal using deep learning algorithms. While a few prior approaches with contrastive learning have been successful, the best way to define a positive sample remains an ...
arxiv  

Cardiac Arrhythmias Following Condenser Discharges Led Through an Inductance: [PDF]

, 1965
B Peleska, Z. Blažk, Michael Rabl, Е. А. Сладкова   +3 more
openalex   +1 more source

Further SAR of GIRK1/2 activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, Accepted Article.
The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany Spitznagel, Sandeep K Singh, Yashpal Chhonker, Daryl J Murry, David Weaver, Corey R Hopkins   +8 more
wiley   +1 more source

Pathology of the Cardiac Conduction System in a Case of Diphtheria Associated with Atrial Arrhythmias and Heart Block [PDF]

, 1963
Thomas N. James, Ernest W. Reynolds
openalex   +1 more source

Cardiac Arrhythmias [PDF]

Postgraduate Medical Journal, 1964
openaire   +2 more sources

Cardiac Arrhythmias Associated with Succinylcholine in a Patient with Pheochromocytoma [PDF]

, 1968
Theodore K. Stoner, KARL F. URBACH
openalex   +1 more source

Fibroblasts, myofibroblasts and cardiac arrhythmias. [PDF]

J Cardiovasc Aging, 2023
Frangogiannis NG.
europepmc   +1 more source

Relationship of Hypoxia to Arrhythmia and Cardiac Conduction Hemorrhage [PDF]

, 1963
Richard E. Clark, Ignacio Y. Christlieb, Miguel E. Sanmarco, Rodrigo Diaz‐Perez, John F. Dammann, Martin E. Zipser   +5 more
openalex   +1 more source