Results 41 to 50 of about 778,376 (312)

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6 [PDF]

, 2012
Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating.
Mano Sitsapesan (182017), Tsaneva-Atanasova, Krasimira, Samantha J Pitt, Pitt Samantha J., Zaccai, N, Krasimira Tsaneva-Atanasova (144624), Sitsapesan, Rebecca, Tsaneva-Atanasova, KT, Pitt, SJ, Stephen O'Neill (182027), Zaccai Nathan R., Tsaneva-Atanasova Krasimira, Sitsapesan Rebecca, O'Neill Stephen, Galfre, Elena, Pitt, Samantha Jane, Nathan R. Zaccai (182021), Venturi Elisa, Sitsapesan, Mano, Mano Sitsapesan, Galfré Elena, Rebecca Sitsapesan (182033), Sitsapesan Mano, Rebecca Sitsapesan, Venturi, E, Galfré, E, Samantha J. Pitt (182004), Tsaneva-Atanasova, K, Stephen O'Neill, Elisa Venturi, Elena Galfré, Elena Galfré (182000), Elisa Venturi (182009), Zaccai, NR, O'Neill, Stephen, Nathan R Zaccai, Sitsapesan, R, O'Neill, S, Krasimira Tsaneva-Atanasova, Venturi, Elisa, Zaccai, Nathan R, Sitsapesan, M   +41 more
core   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Cardiac arrhythmias and pacing [PDF]

Srce i krvni sudovi, 2012
In the last two years, a number of land-mark clinical trials have been published which further our understanding and clinical management of patients with atrial fibrillation (AF). Two of the major goals in the treatment of this condition include reducing pro-gression or recurrence of the arrhythmia and decrea-sing the risk of cardiovascular events ...
openaire   +2 more sources

Mechanisms of Sudden Cardiac Death Oxidants and Metabolism

, 2017
Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel ...
Yang, Kai-Chien;Kyle, John W.;Makielski, Jonathan C.;Dudley, Samuel C., Jr., 楊鎧鍵   +1 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

COMPARATIVE EVALUATION OF PERMANENT CARDIAC PACING IN PACEMAKER-DEPENDENT PATIENTS WITH DIFFERENT PATTERNS OF RIGHT VENTRICLE EXCITATION

Медицинский вестник Юга России, 2015
Purpose: comparative analysis of the effectiveness of permanent cardiac pacing and quality of life in the pacemaker-dependent chronical heart failure patients with different patterns of excitation of the right ventricle.Materials and methods: we examined
V. V. Korshunov, G. V. Chudinov, V. P. Terentiev   +2 more
doaj   +1 more source

No Association Between T-peak to T-end Interval on the Resting ECG and Long-Term Incidence of Ventricular Arrhythmias Triggering ICD Interventions

Frontiers in Physiology, 2020
Background and ObjectivesPotential of using the T-peak to T-end (TpTe) interval as an electrocardiographic parameter reflecting the transmural dispersion of ventricular repolarization (TDR) to identify patients (pts.) with higher risk of malignant ...
Peter Michalek, Sasha Benjamin Hatahet, Martin Svetlosak, Peter Margitfalvi, Iveta Waczulikova, Sebastian Trnovec, Allan Böhm, Allan Böhm, Ondrej Benacka, Ondrej Benacka, Robert Hatala, Robert Hatala   +11 more
doaj   +1 more source

Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19

Frontiers in Physiology, 2022
In the early phases of the COVID-19 pandemic, drug repurposing was widely used to identify compounds that could improve the prognosis of symptomatic patients infected by SARS-CoV-2.
Luca Sala, Vladislav Leonov, Vladislav Leonov, Manuela Mura, Federica Giannetti, Aleksandr Khudiakov, Alessandra Moretti, Alessandra Moretti, Lia Crotti, Lia Crotti, Lia Crotti, Massimiliano Gnecchi, Massimiliano Gnecchi, Peter J. Schwartz   +13 more
doaj   +1 more source

Effects of age on the prevalence of cardiac dysrhythmias in ponies [PDF]

, 2010
This study describes the prevalence of cardiac dysrhythmias occurring over a single 24 h period in ponies and compares the heart rate and frequency of dysrhythmias in two groups of ponies of different ages Electrocardiograms were recorded using a Holter ...
Pirie, Scott; id_orcid, Rezakhani, A., Blissitt, Karen   +2 more
core  

How Cardiac Embryology Translates into Clinical Arrhythmias

, 2021
The electrophysiological signatures of the myocardium in cardiac structures, such as the atrioventricular node, pulmonary veins or the right ventricular outflow tract, are established during development by the spatial and temporal expression of ...
Monique R. M. Jongbloed, Boukens, Bastiaan J., Michiel Blok, Rivaud, Mathilde R., Jongbloed, Monique R. M., Mathilde R. Rivaud, Blok, Michiel, Bastiaan J. Boukens   +7 more
core   +1 more source