Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos +5 more
wiley +1 more source
Long-term survival in patients with premature ventricular complexes and no structural heart disease. [PDF]
Bouleau R +4 more
europepmc +1 more source
ABSTRACT Aims To explore relatives' experiences of the circulatory death of a family member following out‐of‐hospital cardiac arrest and to explore their hypothetical perspectives on being asked to decide about organ donation in this situation. This study forms part of a broader initiative undertaken to assess the prerequisites for implementing ...
Gisela Vogel +3 more
wiley +1 more source
Purkinje de-networking for refractory short-coupled premature ventricular contraction-triggered ventricular fibrillation in dextrocardia with situs inversus. [PDF]
Madadi S +4 more
europepmc +1 more source
Exploring Long‐Term Outcomes in Sepsis Survivors: A Prospective Cohort Study Across Acute Hospitals
ABSTRACT Introduction While sepsis survival rates have improved, long‐term consequences remain under‐recognised and support services limited. Survivors often face persistent physical, cognitive and psychological impairments that diminish their quality of life.
Katie O'Byrne +9 more
wiley +1 more source
Case Report: Atrial fibrillation as the initial presentation of an adult anomalous origin of the left coronary artery from the pulmonary artery. [PDF]
He C, Ma J, Wang W.
europepmc +1 more source
Idiopathic Ventricular Arrhythmias: Map Meticulously, Ablate Sparingly. [PDF]
John RM.
europepmc +1 more source
Premature ventricular complexes increase with heart rate in patients with mitral valve prolapse. [PDF]
Bugge C +10 more
europepmc +1 more source

