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Advanced Science, EarlyView.A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li +22 more
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TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration
Advanced Science, EarlyView.TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu +9 more
wiley +1 more source
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Cardiac Conduction System Pacing
JACC: Clinical Electrophysiology, 2023The field of cardiac pacing has changed rapidly in the last several years. Since the initial description of His bundle pacing targeting the conduction system, recent advances in pacing the left bundle branch and its fascicles have evolved. The field and investigators' knowledge of conduction system pacing including relevant anatomy and physiology has ...
Vijayaraman, Pugazhendhi +15 more
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2016
The atria and the ventricles of the heart contract rhythmically and sequentially to achieve efficient blood flow. This contraction pattern is orchestrated by the cardiac conduction system, comprising specialized cardiomyocytes that initiate and propagate the cardiac electrical impulse.
Mohan, Rajiv, Christoffels, Vincent M.
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The atria and the ventricles of the heart contract rhythmically and sequentially to achieve efficient blood flow. This contraction pattern is orchestrated by the cardiac conduction system, comprising specialized cardiomyocytes that initiate and propagate the cardiac electrical impulse.
Mohan, Rajiv, Christoffels, Vincent M.
+4 more sources
Anatomy of the cardiac conduction system
Pacing and Clinical Electrophysiology, 2020AbstractThe specialized cardiomyocytes that constitute the conduction system in the human heart, initiate the electric impulse and result in rhythmic and synchronized contraction of the atria and ventricles. Although the atrioventricular (AV) conduction axis was described more than a century ago by Sunao Tawara, the anatomic pathway for propagation of ...
Santosh K. Padala +2 more
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Development of the cardiac conduction system
Seminars in Cell & Developmental Biology, 2007The cardiac conduction system (CCS) is a specialized tissue network that initiates and maintains a rhythmic heartbeat. The CCS consists of several functional subcomponents responsible for producing a pacemaking impulse and distributing action potentials across the heart in a coordinated manner.
Takashi, Mikawa, Romulo, Hurtado
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2014
The anatomy of cardiac conduction system and genetic mutations that have been associated with conduction disease are discussed.
Demosthenes G. Katritsis +2 more
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The anatomy of cardiac conduction system and genetic mutations that have been associated with conduction disease are discussed.
Demosthenes G. Katritsis +2 more
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Cardiac Conduction System Development
2001A rhythmic heart beat is coordinated by pacemaking impulses generated and conducted through the excitation-conduction system. The physiologic, anatomic, and cellular characteristics of this specialized cardiac tissue have been studied in great detail in the last decades.
Takashi Mikawa +3 more
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