Results 241 to 250 of about 141,036 (291)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

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Cardiac Conduction System Pacing

JACC: Clinical Electrophysiology, 2023
The field of cardiac pacing has changed rapidly in the last several years. Since the initial description of His bundle pacing targeting the conduction system, recent advances in pacing the left bundle branch and its fascicles have evolved. The field and investigators' knowledge of conduction system pacing including relevant anatomy and physiology has ...
Vijayaraman, Pugazhendhi, Chelu, Mihal G, Curila, Karol, Dandamudi, Gopi, Herweg, Bengt, Mori, Shumpei, Jastrzebski, Marek, Sharma, Parikshit S, Shivkumar, Kalyanam, Tung, Roderick, Upadhyay, Gaurav, Vernooy, Kevin, Welter-Frost, Allan, Whinnett, Zachary, Zanon, Francesco, Ellenbogen, Kenneth A   +15 more
exaly   +5 more sources

Cardiac Conduction System

2016
The atria and the ventricles of the heart contract rhythmically and sequentially to achieve efficient blood flow. This contraction pattern is orchestrated by the cardiac conduction system, comprising specialized cardiomyocytes that initiate and propagate the cardiac electrical impulse.
Mohan, Rajiv, Christoffels, Vincent M.
  +4 more sources

Anatomy of the cardiac conduction system

Pacing and Clinical Electrophysiology, 2020
AbstractThe specialized cardiomyocytes that constitute the conduction system in the human heart, initiate the electric impulse and result in rhythmic and synchronized contraction of the atria and ventricles. Although the atrioventricular (AV) conduction axis was described more than a century ago by Sunao Tawara, the anatomic pathway for propagation of ...
Santosh K. Padala, José‐Angel Cabrera, Kenneth A. Ellenbogen   +2 more
openaire   +2 more sources

Development of the cardiac conduction system

Seminars in Cell & Developmental Biology, 2007
The cardiac conduction system (CCS) is a specialized tissue network that initiates and maintains a rhythmic heartbeat. The CCS consists of several functional subcomponents responsible for producing a pacemaking impulse and distributing action potentials across the heart in a coordinated manner.
Takashi, Mikawa, Romulo, Hurtado
openaire   +2 more sources

The cardiac conduction system

2014
The anatomy of cardiac conduction system and genetic mutations that have been associated with conduction disease are discussed.
Demosthenes G. Katritsis, Bernard J. Gersh, A. John Camm   +2 more
openaire   +1 more source

Cardiac Conduction System Development

2001
A rhythmic heart beat is coordinated by pacemaking impulses generated and conducted through the excitation-conduction system. The physiologic, anatomic, and cellular characteristics of this specialized cardiac tissue have been studied in great detail in the last decades.
Takashi Mikawa, Robert G. Gourdie, Jeanette Hyer, Kimiko Takebayashi-Suzuki   +3 more
openaire   +1 more source