Results 231 to 240 of about 178,867 (336)

TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy.

Human Molecular Genetics, 2014
Jeanne L. Theis, Michael T. Zimmermann, Brandon T. Larsen, I. Rybakova, Pamela A. Long, Jared Evans, S. Middha, M. de Andrade, R. Moss, E. Wieben, V. Michels, T. Olson   +11 more
semanticscholar   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Tailoring Anesthesia for Cardiac Amyloidosis: A Case Report Highlighting Perioperative Challenges. [PDF]

Cureus
Fernandes ASM, Cavaleiro C, Pombo A.
europepmc   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

The Conducting Tissues of the Mouse Heart. [PDF]

J Cardiovasc Dev Dis
Macías Y, Sánchez-Quintana D, Sternick EB, Anderson RH.   +3 more
europepmc   +1 more source

Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease

Movement Disorders Clinical Practice, 2018
Christopher D. Stephen, J. Hung, G. Schifitto, S. Hersch, H. Rosas   +4 more
semanticscholar   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Arrhythmogenic Risk in iPSC-Derived Cardiomyocytes: Current Limitations and Therapeutic Perspectives. [PDF]

Medicina (Kaunas)
Shahannaz DC, Sugiura T, Ferrell BE, Yoshida T.   +3 more
europepmc   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Conduction system pacing in a patient with persistent left superior vena cava and absent right superior vena cava: a case report. [PDF]

J Med Case Rep
Rodriguez-Queralto O, Gonzalez-Matos C, Zaraket F, Casteig B, Jimenez-Lopez J, Valles E.   +5 more
europepmc   +1 more source