Results 271 to 280 of about 116,699 (313)

The cardiac conduction system: History, development, and disease

The heart is the first organ to form during embryonic development, establishing the circulatory infrastructure necessary to sustain life and enable downstream organogenesis. Critical to the heart's function is its ability to initiate and propagate electrical impulses that allow for the coordinated contraction and relaxation of its chambers, and thus ...
Carissa Lee, Sidra Xu, Tahmina Samad, William R. Goodyer, Alireza Raissadati, Paul V. Heinrich, Sean M. Wu   +6 more
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Hypertrophic Cardiomyopathy and Symptomatic Conduction System Disease in Cardiac Amyloidosis

Southern Medical Journal, 2006
Cardiac involvement is the most important prognostic factor in primary amyloidosis (AL). The clinical presentation of amyloid cardiomyopathy is varied and may manifest as heart failure, brady or tachyarrhythmias, syncope, angina and rarely with features of hypertrophic cardiomyopathy and advanced symptomatic conduction system disease. The management of
Praveen Garg, Ruchi Gupta, David H. Hsi, Lucy A. Sheils, Michael DiSalle, Timothy J. Woodlock   +5 more
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Incidence and prognosis of cardiac conduction system diseases in hypertension: the STEP trial

Nature Aging
Patients with cardiac conduction system diseases (CSD) may have increased incidence and mortality of cardiovascular events. Here we report a post hoc analysis of the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) randomized clinical trial (ClinicalTrials.gov number, NCT03015311) concerning the effect of intensive ...
Song Zhao, Yue Deng, Yixuan Wang, Shikai Yu, Jun Han, Jun Cai, Yi Zhang   +6 more
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Cardiac conduction system in rheumatic heart disease.

The Indian journal of medical research, 1982
Paramjeet S. Chopra, U. Sabherwal
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Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson’s disease: an anatomical study

Acta Neuropathologica, 2009
Clinical and autopsy studies have consistently reported cardiac sympathetic dysfunction in the left ventricular wall in patients with Parkinson's disease (PD). Whether the nerve fibers of the cardiac conduction system or the atrial walls are equally affected in this disease process has not yet been well documented.
Estifanos Ghebremedhin, Kelly Del Tredici, J. William Langston, Heiko Braak   +3 more
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Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease [PDF]

Journal of Molecular and Cellular Cardiology, 2007
Mutations in the lamin A/C (LMNA) gene, which encodes nuclear membrane proteins, cause a variety of human conditions including dilated cardiomyopathy (DCM) with associated cardiac conduction system disease. To investigate mechanisms responsible for electrophysiologic and myocardial phenotypes caused by dominant human LMNA mutations, we performed ...
Cordula M. Wolf, Libin Wang, Ronny Alcalai, Anne Pizard, Patrick G. Burgon, Ferhaan Ahmad, Megan Sherwood, Dorothy Branco, Hiroko Wakimoto, Glenn I. Fishman, Vincent See, Colin L. Stewart, David A. Conner, Charles I. Berul, Christine E. Seidman, Jonathan G. Seidman   +15 more
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Conduction system disease in cardiac amyloidosis

Trends in Cardiovascular Medicine
Cardiac amyloidosis (CA) has diverse and deleterious effects on the conductive system. Atrial fibrillation is by far the most common electrophysiological manifestation of CA and is associated with more mortality, morbidity, and hospitalizations. While AF increases the risk of thrombosis regardless of the CHA2DS2-VASc score, the risk of thromboembolism ...
Ala’ Assaf, Mario Mekhael, Charbel Noujaim, Nour Chouman, Hadi Younes, Omar Kreidieh, Nassir Marrouche, Eoin Donnellan   +7 more
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Electrophysiologic effects of intravenous magnesium in patients with normal conduction systems and no clinical evidence of significant cardiac disease

American Heart Journal, 1988
Parenteral magnesium has been used for several decades in the empiric treatment of various arrhythmias, but the data on its electrophysiologic effects in man are limited. We evaluated the electrophysiologic effects of magnesium sulfate (MgSO4) administration in eight normomagnesemic patients with normal mononuclear cell magnesium content, who had no ...
Michael I. Kulick, Robert Hong, Elisabeth Ryzen, Robert K. Rude, J. Nathan Rubin, Uri Elkayam, Shahbudin H. Rahimtoola, Anil K. Bhandari   +7 more
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Intensive blood pressure control does not lower risk of cardiac conduction system diseases

Nature Aging

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Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease

American Journal of Physiology-Heart and Circulatory Physiology, 2007
Some mutations of the sodium channel gene NaV1.5 are multifunctional, causing combinations of LQTS, Brugada syndrome and progressive cardiac conduction system disease (PCCD). The combination of Brugada syndrome and PCCD is uncommon, although they both result from a reduction in the sodium current.
Zhu-Shan, Zhang, Joseph, Tranquillo, Valentina, Neplioueva, Nenad, Bursac, Augustus O, Grant   +4 more
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