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The cardiac conduction system: History, development, and disease.
Current Topics in Developmental BiologyThe heart is the first organ to form during embryonic development, establishing the circulatory infrastructure necessary to sustain life and enable downstream organogenesis. Critical to the heart's function is its ability to initiate and propagate electrical impulses that allow for the coordinated contraction and relaxation of its chambers, and thus ...
Carissa Lee +6 more
semanticscholar +3 more sources
American Journal of Physiology-Heart and Circulatory Physiology, 2007
Some mutations of the sodium channel gene NaV1.5 are multifunctional, causing combinations of LQTS, Brugada syndrome and progressive cardiac conduction system disease (PCCD). The combination of Brugada syndrome and PCCD is uncommon, although they both result from a reduction in the sodium current.
Zhu-shan Zhang +4 more
semanticscholar +3 more sources
Some mutations of the sodium channel gene NaV1.5 are multifunctional, causing combinations of LQTS, Brugada syndrome and progressive cardiac conduction system disease (PCCD). The combination of Brugada syndrome and PCCD is uncommon, although they both result from a reduction in the sodium current.
Zhu-shan Zhang +4 more
semanticscholar +3 more sources
Conduction System Disease in Fetuses Evaluated for Irregular Cardiac Rhythm
Fetal Diagnosis and Therapy, 2006<i>Objectives:</i> To determine the prevalence of 1st and 2nd degree AV block in fetuses with an irregular cardiac rhythm, and to summarize outcome of these pregnancies. <i>Background:</i> The diagnosis of irregular cardiac rhythm or ‘skipped beats’ includes isolated ectopy that resolves spontaneously.
B. Cuneo +3 more
semanticscholar +3 more sources
Hypertrophic Cardiomyopathy and Symptomatic Conduction System Disease in Cardiac Amyloidosis
Southern Medical Journal, 2006Cardiac involvement is the most important prognostic factor in primary amyloidosis (AL). The clinical presentation of amyloid cardiomyopathy is varied and may manifest as heart failure, brady or tachyarrhythmias, syncope, angina and rarely with features of hypertrophic cardiomyopathy and advanced symptomatic conduction system disease. The management of
P. Garg +5 more
semanticscholar +3 more sources
Molecular and Cellular Biochemistry, 2013
The LMNA gene, which encodes the nuclear envelope protein lamin A/C, is considered to be the most common autosomal disease gene associated with familial dilated cardiomyopathy. To date, each mutation of the LMNA gene has been associated with a specific disease phenotype.
Wenting Chen +4 more
semanticscholar +3 more sources
The LMNA gene, which encodes the nuclear envelope protein lamin A/C, is considered to be the most common autosomal disease gene associated with familial dilated cardiomyopathy. To date, each mutation of the LMNA gene has been associated with a specific disease phenotype.
Wenting Chen +4 more
semanticscholar +3 more sources
Acta Neuropathologica, 2009
Clinical and autopsy studies have consistently reported cardiac sympathetic dysfunction in the left ventricular wall in patients with Parkinson's disease (PD). Whether the nerve fibers of the cardiac conduction system or the atrial walls are equally affected in this disease process has not yet been well documented.
E. Ghebremedhin +3 more
semanticscholar +4 more sources
Clinical and autopsy studies have consistently reported cardiac sympathetic dysfunction in the left ventricular wall in patients with Parkinson's disease (PD). Whether the nerve fibers of the cardiac conduction system or the atrial walls are equally affected in this disease process has not yet been well documented.
E. Ghebremedhin +3 more
semanticscholar +4 more sources
Progress in Cardiovascular Diseases, 2005
Throughout the cardiac conduction system of each heart there were numerous destructive lesions including focal inflammatory infiltration with lymphocytes and in neighboring regions extensive focal fibrotic degeneration. These lesions involved myocytes, nerves and blood vessels.
T. James, M. Rossi, Shoji Yamamoto
semanticscholar +3 more sources
Throughout the cardiac conduction system of each heart there were numerous destructive lesions including focal inflammatory infiltration with lymphocytes and in neighboring regions extensive focal fibrotic degeneration. These lesions involved myocytes, nerves and blood vessels.
T. James, M. Rossi, Shoji Yamamoto
semanticscholar +3 more sources
Conduction System Pacing for Patients with Congenital Heart Disease.
Cardiac Electrophysiology Clinics, 2023For patients with congenital heart disease (CHD), chronic ventricular pacing may lead to progressive cardiomyopathy owing to electromechanical dyssynchrony.
J. Moore, Aarti Dalal
semanticscholar +1 more source
Conduction System Pacing for Cardiac Resynchronization Therapy.
Cardiac Electrophysiology Clinics, 2022Although conventional biventricular pacing has been shown to benefit patients with heart failure and conduction system disease, there are limitations to its therapeutic success, resulting in widely variable clinical response.
B. Herweg +3 more
semanticscholar +1 more source
Circulation Research, 2023
Rhythmic beating of the heart is driven by a small subset of heart cells, altogether known as the cardiac conduction system (CCS). The CCS consists of unique components including the sinoatrial node (SAN), the atrioventricular node (AVN), the bundle of His, bundle branches and Purkinje fiber (PF) system.
Benjamin Beyersdorf +3 more
openaire +1 more source
Rhythmic beating of the heart is driven by a small subset of heart cells, altogether known as the cardiac conduction system (CCS). The CCS consists of unique components including the sinoatrial node (SAN), the atrioventricular node (AVN), the bundle of His, bundle branches and Purkinje fiber (PF) system.
Benjamin Beyersdorf +3 more
openaire +1 more source