Results 91 to 100 of about 2,864,293 (283)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

On the Einthoven Triangle: A Critical Analysis of the Single Rotating Dipole Hypothesis

Sensors, 2018
Since its inception, electrocardiography has been based on the simplifying hypothesis that cardinal limb leads form an equilateral triangle of which, at the center/centroid, the electrical equivalent of the cardiac activity rotates during the cardiac ...
Gaetano D. Gargiulo, Paolo Bifulco, Mario Cesarelli, Alistair L. McEwan, Hossein Moeinzadeh, Aiden O’Loughlin, Ibrahim M. Shugman, Jonathan C. Tapson, Aravinda Thiagalingam   +8 more
doaj   +1 more source

Cardiac Cycle Estimation for BOLD-fMRI [PDF]

, 2018
Previous studies [1, 2] have shown that slow variations in the cardiac cycle are coupled with signal changes in the blood-oxygen level dependent (BOLD) contrast. The detection of neurophysiological hemodynamic changes, driven by neuronal activity, is hampered by such physiological noise.
Michael Hütel, Andrew Melbourne, David L. Thomas, Sébastien Ourselin   +3 more
openaire   +3 more sources

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Cardiac Urea Cycle Activation by Time‐Restricted Feeding Protects Against Pressure Overload‐Induced Heart Failure

Advanced Science
Heart failure is a leading cause of mortality worldwide, necessitating the development of novel therapeutic and lifestyle interventions. Recent studies highlight a potential role of time‐restricted feeding (TRF) in the prevention and treatment of cardiac
Yanzhen Tan, Min Li, Han Li, Yongzheng Guo, Bing Zhang, Guiling Wu, Jia Li, Qian Zhang, Yang Sun, Feng Gao, Wei Yi, Xing Zhang   +11 more
doaj   +1 more source

A review of heart chamber segmentation for structural and functional analysis using cardiac magnetic resonance imaging [PDF]

, 2016
Cardiovascular magnetic resonance (CMR) has become a key imaging modality in clinical cardiology practice due to its unique capabilities for non-invasive imaging of the cardiac chambers and great vessels. A wide range of CMR sequences have been developed
Frangi, A.F., Peng, Peng, Frangi, Alejandro F.; id_orcid, Frangi, Alejandro F., Petersen, SE, Gooya, A., Petersen, S.E., Peng, P, Peng, P., Petersen, Steffen E., Lekadir, K, Frangi Caregnato, Alejandro, Shao, L, Shao, Ling, Petersen, Steffen, Lekadir, Karim, 1977-, Lekadir, K., Gooya, A, Shao, L., Frangi, AF, Lekadir, Karim, Gooya, Ali   +21 more
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

A prospective study to evaluate the accuracy of pulse power analysis to monitor cardiac output in critically ill patients [PDF]

, 2008
Background Intermittent measurement of cardiac output may be performed using a lithium dilution technique (LiDCO). This can then be used to calibrate a pulse power algorithm of the arterial waveform which provides a continuous estimate of this variable ...
Maurizio Cecconi, Fawcett, J, Rhodes, A, Jayne Fawcett, Fawcett Jayne, Rhodes Andrew, R Michael Grounds, Grounds, RM, Grounds R Michael, Cecconi Maurizio, Andrew Rhodes, Cecconi, M   +11 more
core   +2 more sources

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Measuring left ventricular volumes in two-dimensional echocardiography image sequence using level-set method for automatic detection of end-diastole and end-systole frames

Research in Cardiovascular Medicine, 2013
Background: Identifying End-Diastole (ED) and End-Systole (ES) frames is highly important in the process of evaluating cardiac function and measuring global parameters accurately, such as Ejection Fraction (EF), Cardiac Output (CO) and Stroke Volume ...
Saeed Darvishi, Hamid Behnam, Majid Pouladian, Niloufar Samiei   +3 more
doaj   +1 more source