Results 271 to 280 of about 534,991 (349)

Glucocorticoids Improve Calcium Cycling in Cardiac Myocytes After Cardiopulmonary Bypass [PDF]

, 2009
Jeffrey M. Pearl, David M. Plank, Kelly M. McLean, Connie J. Wagner, Jodie Y. Duffy   +4 more
openalex   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Timing along the cardiac cycle modulates neural signals of reward-based learning

, 2022
Fouragnan E, Hosking B, Cheung Y, Prakash B, Rushworth M, Sel A.   +5 more
europepmc   +1 more source

Intermediate mechanical index triggered replenishment (every cardiac cycle) myocardial contrast echocardiography: A new and accurate method for the assessment of coronary artery disease

, 2003
Paramjit Jeetley, Michael Hickman, Roxy Senior   +2 more
openalex   +1 more source

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Influence of the cardiac cycle on velocity selective and acceleration selective arterial spin labeling. [PDF]

Magn Reson Med, 2020
Franklin SL, Schmid S, Bos C, van Osch MJP.   +3 more
europepmc   +1 more source

Adaptation to Low-Intensity Exercise on a Cycle Ergometer by Patients With Acute Myocardial Infarction Undergoing Phase I Cardiac Rehabilitation

, 2004
Atsuhiko Matsunaga, Takashi Masuda, Misao Ogura, Masakazu Saitoh, Yusuke Kasahara, Takami Iwamura, Minako Yamaoka‐Tojo, Kiyotaka Sato, Tohru Izumi   +8 more
openalex   +2 more sources

Multiple-cardiac-cycle noise reduction in dynamic optical coherence tomography of the embryonic heart and vasculature [PDF]

, 2009
Sandeep Bhat, Irina V. Larina, Kirill V. Larin, Mary E. Dickinson, Michael Liebling   +4 more
openalex   +1 more source

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao, Xi Zhang, Shuan Ran, Yuan Li, Weicong Ye, Song Wang, Xiaohan Li, Zilong Luo, Jiulu Zhao, Junjie Zong, Kexiao Zheng, Ran Li, Han Zhang, Longyong Lai, Pinyan Huang, Zifeng Zou, Wang Zhan, Zhang Yue, Jie Wu, Jiahong Xia   +19 more
wiley   +1 more source

Disentangling sensorimotor and cognitive cardioafferent effects: A cardiac-cycle-time study on spatial stimulus-response compatibility. [PDF]

Sci Rep, 2020
Larra MF, Finke JB, Wascher E, Schächinger H.   +3 more
europepmc   +1 more source