Results 111 to 120 of about 1,050,190 (380)

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Epigenetic Biomarkers in Cardiovascular Diseases

Frontiers in Genetics, 2019
Cardiovascular diseases are the number one cause of death worldwide and greatly impact quality of life and medical costs. Enormous effort has been made in research to obtain new tools for efficient and quick diagnosis and predicting the prognosis of ...
Carolina Soler-Botija, Carolina Soler-Botija, Carolina Gálvez-Montón, Carolina Gálvez-Montón, Antoni Bayés-Genís, Antoni Bayés-Genís, Antoni Bayés-Genís, Antoni Bayés-Genís   +7 more
doaj   +1 more source

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. [PDF]

, 2019
Increased adrenergic tone resulting from cardiovascular stress leads to development of heart failure, in part, through chronic stimulation of β1 adrenergic receptors (βARs) on cardiac myocytes.
Irannejad, Roshanak, Nash, Craig A, Smrcka, Alan V, Wei, Wenhui   +3 more
core   +1 more source

Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure [PDF]

, 2016
Mitochondrial (mt) DNA depletion and oxidative mtDNA damage have been implicated in the process of pathological cardiac remodeling. Whether these features are present in the early phase of maladaptive cardiac remodeling, that is, during compensated ...
Bargelli, Valentina, Bates, Matthew GD, CERBELLI, BRUNA, D'AMATI, Giulia, Della Monica, Paola Lilla, FAMILIARI, Giuseppe, GIORDANO, Carla, He, Langping, Lucena, Joaquin R, MANCINI, MASSIMILIANO, Nediani, Chiara, PELULLO, MARIA, PERLI, ELENA, PETROZZA, Vincenzo, PISANO, ANNALINDA, Preziuso, Carmela, Taylor, Robert W   +16 more
core   +3 more sources

Cardiac Function and Heart Failure

Journal of the American College of Cardiology, 2006
For the ACC.06 Scientific Sessions, the Program Committee received 736 submissions in the area of heart failure (HF), 244 of which were accepted for presentation. Although there were a limited number of large HF clinical trials, HF and cardiac function topics were well represented in various ...
Christopher M. O'Connor, Lynne E. Wagoner, Randall C. Starling   +2 more
openaire   +3 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

ROC Analysis and a Realistic Model of Heart Rate Variability [PDF]

arXiv, 1998
We have carried out a pilot study on a standard collection of electrocardiograms from patients who suffer from congestive heart failure, and subjects without cardiac pathology, using receiver-operating-characteristic (ROC) analysis. The scale-dependent wavelet-coefficient standard deviation \sigma_{wav}(m), a multiresolution-based analysis measure, is ...
arxiv  

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]

, 2016
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta, Gong, Ke Wei, Lusis, Aldons J, Rau, Christoph, Ren, Shuxun, Romay, Milagros C, Stolin, Gabriel, Wang, Jessica Jen-Chu, Wang, Yibin   +8 more
core   +7 more sources

Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse [PDF]

, 2017
Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized ...
Abbate, A., Buzzetti, Raffaella, Carbone, Salvatore, Lee, P. J. H., Mauro, A. G., Mezzaroma, E., Toldo, S., Van Tassell, B.   +7 more
core   +2 more sources

Direct Ink Writing of Conductive Hydrogels

Advanced Functional Materials, EarlyView.
This review examines the use of direct ink writing (DIW) for fabricating conductive hydrogels with customizable 3D structures. It outlines the rheological requirements for successful DIW, followed by an exploration of the materials and ink formulations used to impart electronic and/or ionic conductivity to hydrogels while maintaining printability ...
Monica Ho, Aline Braz Ramirez, Negar Akbarnia, Eric Croiset, Elisabeth Prince, Gerald G. Fuller, Milad Kamkar   +6 more
wiley   +1 more source