Results 121 to 130 of about 4,737,690 (404)

Cardiac-resynchronization therapy for mild-to-moderate heart failure.

New England Journal of Medicine, 2010
BACKGROUND Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular systolic dysfunction and a wide QRS complex. Most of these patients are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding
A. Tang, G. Wells, M. Talajic, M. Arnold, R. Sheldon, S. Connolly, S. Hohnloser, G. Nichol, D. Birnie, J. Sapp, R. Yee, J. Healey, J. Rouleau   +12 more
semanticscholar   +1 more source

Engineering Anisotropic Mechanical Properties in Large‐Scale Fabricated Cartilage Constructs Using Microfiber Reinforcement

Advanced Healthcare Materials, EarlyView.
This study presents the development of large‐scale (15 cm2) cartilage constructs with anisotropic mechanical properties using melt electrowritten (MEW) microfiber reinforced cell‐laden gelatin methacryloyl (gelMA). These constructs mimic the mechanical behavior of native cartilage, providing a suitable environment for Articular Cartilage ...
Lennard Spauwen, Alba Pueyo Moliner, Patrick van Veenendaal, Roel Custers, Jos Malda, Mylène de Ruijter   +5 more
wiley   +1 more source

Cardiac Function and Heart Failure

Journal of the American College of Cardiology, 2005
A total of 811 abstracts were submitted in the area of Cardiac Function and Heart Failure. These are shown by sub-topic in [Figure 1][1].Each abstract was evaluated by 5 to 7 reviewers, 281 were selected for presentation, and 19 are highlighted in the following review.
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida ( host institution ), Pauly, Daniel F. ( author )   +1 more
openaire   +4 more sources

Cardiac myosin-Th17 responses promote heart failure in human myocarditis.

JCI Insight, 2016
In human myocarditis and its sequela dilated cardiomyopathy (DCM), the mechanisms and immune phenotype governing disease and subsequent heart failure are not known.
J. Myers, L. Cooper, D. Kem, S. Stavrakis, S. Kosanke, E. Shevach, D. Fairweather, J. Stoner, Carol J. Cox, M. Cunningham   +9 more
semanticscholar   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

The Memory of the Heart

Journal of Cardiovascular Development and Disease, 2018
The embryological development of the heart is one of the most fascinating phenomena in nature and so is its final structure and function. The various ontogenetic passages form the evolutive basis of the final configuration of the heart. Each key step can
Marco Cirillo
doaj   +1 more source

Getting to the Heart of the Matter Evaluation Report: Post-Acute Cardiac Rehabilitation Program to Reduce Hospital Readmissions [PDF]

, 2015
Launched in 2013, this innovative program was designed to help cardiac patients achieve success with their post-acute treatment regime, something that is especially important for older cardiac patients who are at an increased risk for complications.
Denise D. Quigley, Thomas F. Syltebo
core  

Single beat determination of intraventricular systolic dyssynchrony in paitents with atrial fibrillation and systolic dysfunction [PDF]

, 2013
Background:: Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia. However, diagnosis of intraventricular dyssynchrony in patients with AF is difficult due to beat-to-beat variation. Additionally, evaluation of mechanical
Aghapour, Sevil, Alizadehsani, Zahra, Haghjoo, Majid, Hoghooghi, Alireza, Rezaei, Mohsen, Sadeghpour, Anita   +5 more
core   +1 more source

Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment

Nature Communications, 2016
Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that crosslinks collagen—Lysyl oxidase-like 2 (Loxl2)—is essential for interstitial fibrosis and mechanical dysfunction of ...
Jin Yang, K. Savvatis, J. Kang, P. Fan, H. Zhong, K. Schwartz, V. Barry, Amanda Mikels-Vigdal, S. Karpinski, D. Kornyeyev, J. Adamkewicz, Xuhui Feng, Qiong Zhou, Ching Shang, Praveen Kumar, D. Phan, M. Kašner, B. López, J. Díez, K. Wright, R. Kovacs, Peng-Sheng Chen, T. Quertermous, V. Smith, L. Yao, C. Tschöpe, C. Chang   +26 more
semanticscholar   +1 more source

Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D‐Printed Titanium Truss

Advanced Healthcare Materials, EarlyView.
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo   +9 more
wiley   +1 more source