Results 81 to 90 of about 4,737,690 (404)

Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]

open access: yes, 2014
The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat   +13 more
core   +1 more source

New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging

open access: yesFrontiers in Pharmacology, 2018
Heart failure (HF) has become increasingly common within the elderly population, decreasing their survival and overall quality of life. In fact, despite the improvements in treatment, many elderly people suffer from cardiac dysfunction (HF, valvular ...
Claudio de Lucia, A. Eguchi, W. Koch
semanticscholar   +1 more source

CAR T cells produced in vivo to treat cardiac injury

open access: yesScience, 2022
Description Making CAR T cells in vivo Cardiac fibrosis is the stiffening and scarring of heart tissue and can be fatal. Rurik et al. designed an immunotherapy strategy to generate transient chimeric antigen receptor (CAR) T cells that can recognize the ...
Joel G. Rurik   +17 more
semanticscholar   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Berlin Heart EXCOR® pediatric ventricular assist device in a patient with Sotos syndrome: a case report

open access: yesJournal of Medical Case Reports, 2019
Introduction Berlin Heart EXCOR® pediatric ventricular assist device is a mechanical circulatory support device currently used in pediatric patients. Sotos syndrome is a well-described multiple anomaly syndrome characterized by overgrowth, distinctive ...
Rita Gravino   +8 more
doaj   +1 more source

Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure

open access: yesFrontiers in Cardiovascular Medicine, 2019
Endothelial cells are, by number, one of the most abundant cell types in the heart and active players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in maintaining cardiac vascularization and perfusion during physiological ...
Rajinikanth Gogiraju   +2 more
semanticscholar   +1 more source

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone   +19 more
wiley   +1 more source

Synergistic effects of cardiac resynchronization therapy and drug up-titration in heart failure. is this enough? [PDF]

open access: yes, 2015
This editorial refers to ‘Optimization of heart failure medication after cardiac resynchronization therapy and the impact on long-term survival’, by C.T.
FRANCIA, Pietro, VOLPE, Massimo
core   +1 more source

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

open access: yesNature Communications, 2018
Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte remodeling and clarify distinct cardiomyocyte gene programs encoding ...
S. Nomura   +19 more
semanticscholar   +1 more source

Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure

open access: yesEuropean Journal of Heart Failure, 2021
In this document, we propose a universal definition of heart failure (HF) as a clinical syndrome with symptoms and/or signs caused by a structural and/or functional cardiac abnormality and corroborated by elevated natriuretic peptide levels and/or ...
B. Bozkurt   +37 more
semanticscholar   +1 more source

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