Results 41 to 50 of about 1,502,760 (361)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Hypertension and its correlation with autonomic nervous system dysfunction, heart rate variability and chronic inflammation

Blood Pressure
Objective This study investigates the relationship between hypertension, dysregulation of the autonomic nervous system, heart rate variability (HRV), and chronic inflammation.Methods We analysed a cohort of 50 hypertensive patients treated at the ...
Bo He, Dapeng Ji, Bo Zhang
doaj   +1 more source

Following one's heart: cardiac rhythms gate central initiation of sympathetic reflexes [PDF]

, 2009
Central nervous processing of environmental stimuli requires integration of sensory information with ongoing autonomic control of cardiovascular function.
Critchley, Hugo D, Gray, Marcus A, Harrison, Neil A, Rylander, Karin, Wallin, B Gunnar   +4 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Survival of in-hospital cardiac arrest in men and women in a large Swedish cohort

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2018
Background Cardiac arrest is more common in men than women and a few studies have shown inferior 30-day survival for men than for women. The difference might relate to patient characteristics, intra arrest factors or post arrest care.
Angelika Qvick, Manar Radif, Caroline Brever, Jenny Olsson Myrvik, Karin Schenk Gustafsson, Therese Djärv   +5 more
doaj   +1 more source

PON2 ameliorates Ang II‐induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway

Immunity, Inflammation and Disease, 2023
Background The incidence of heart failure (HF) presents an escalating trend annually, second only to cancer. Few literatures are available regarding on the role of paraoxonase 2 (PON2) in HF so far despite the protective role of PON2 in cardiovascular ...
Yuanzheng Ye, Jian Zhang, Yankai Guo, Jiajun Zhu, Baopeng Tang, Ping Fan   +5 more
doaj   +1 more source

Multiresolution spatiotemporal mechanical model of the heart as a prior to constrain the solution for 4D models of the heart. [PDF]

, 2019
In several nuclear cardiac imaging applications (SPECT and PET), images are formed by reconstructing tomographic data using an iterative reconstruction algorithm with corrections for physical factors involved in the imaging detection process and with ...
Gullberg, Grant T, Liu, Jing, Ordovas, Karen, Segars, W Paul, Seo, Youngho, Shrestha, Uttam M, Veress, Alexander I   +6 more
core   +2 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9

Cell Communication and Signaling
Background Diabetic angiogenesis is closely associated with disabilities and death caused by diabetic microvascular complications. Advanced glycation end products (AGEs) are abnormally accumulated in diabetic patients and are a key pathogenic factor for ...
Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo   +13 more
doaj   +1 more source

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy [PDF]

, 2008
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies results from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2).
Ahmad, F, Banerjee, SK, Conner, DA, Huang, XN, Janczewski, AM, Keller, BB, Lage, ML, Mathier, MA, Moskowitz, IP, Perez-Atayde, AR, Rager, J, Saba, S, Seidman, CE, Seidman, JG, Shroff, SG, Smith, SH, Tinney, JP, Tobita, K   +17 more
core   +4 more sources