Results 51 to 60 of about 1,546,717 (359)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Prediction model and scoring system for in-hospital mortality risk in infants with heart failure aged 1–36 months: A retrospective case-control study

Heliyon
Background: Existing studies report very few factors influencing the mortality of infant and toddler heart failure patients during hospitalization. Due to its high mortality rate, it is an important health issue. Therefore, this study aims to explore the
Meng Wei, Shuai Shang, Huasheng Lv, Xiaoyan Liang, Yanmei Lu, Baopeng Tang   +5 more
doaj   +1 more source

The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila [PDF]

, 2018
Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure.
Hartley, Paul S., Marley, Richard, Miellet, Sara, Vaughan, Leigh   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Survival of in-hospital cardiac arrest in men and women in a large Swedish cohort

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2018
Background Cardiac arrest is more common in men than women and a few studies have shown inferior 30-day survival for men than for women. The difference might relate to patient characteristics, intra arrest factors or post arrest care.
Angelika Qvick, Manar Radif, Caroline Brever, Jenny Olsson Myrvik, Karin Schenk Gustafsson, Therese Djärv   +5 more
doaj   +1 more source

Quadriscupid aortic valve with concurrent aortic stenosis and insufficiency [PDF]

, 2016
We present the case of a 22-year-old man with a congenital mixed aortic valve dysfunction who underwent cardiac Magnetic Resonance Imaging (MRI) for the assessment of aortic valve morphology and function prior to valve replacement.
Devos, Daniel, VAN MEERBEECK, STEPHEN, VANDEN BOSSCHE, STEPHANIE   +2 more
core   +3 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Risk stratification by systemic manifestations secondary to hemodynamic disorders of patients with severe tricuspid regurgitation

BMC Cardiovascular Disorders
Background Tricuspid regurgitation (TR) is a prevalent disease that triggers systemic pathological changes including cardiac, respiratory, hepatic and digestive, hematopoietic, renal and skin issues.
Xing-Yu Ji, Lei Zhu, Fei Chen, Fang-Lin Lu, Yuan Feng, Mao Chen, Tian-Yuan Xiong   +6 more
doaj   +1 more source

PON2 ameliorates Ang II‐induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway

Immunity, Inflammation and Disease, 2023
Background The incidence of heart failure (HF) presents an escalating trend annually, second only to cancer. Few literatures are available regarding on the role of paraoxonase 2 (PON2) in HF so far despite the protective role of PON2 in cardiovascular ...
Yuanzheng Ye, Jian Zhang, Yankai Guo, Jiajun Zhu, Baopeng Tang, Ping Fan   +5 more
doaj   +1 more source

Assessment of Cardiac Function and Ventricular Mechanical Synchronization in Left Bundle Branch Area Pacing by Speckle Tracking and Three-Dimensional Echocardiography [PDF]

, 2022
Yingchen Mei, Rui Han, Liting Cheng, Rongjuan Li, Yihua He, Jinjie Xie, Zefeng Wang, Yongquan Wu   +7 more
openalex   +1 more source