Results 61 to 70 of about 1,546,717 (359)

Enhanced Na\u3csup\u3e+\u3c/sup\u3e/H\u3csup\u3e+\u3c/sup\u3e Exchange During Ischemia and Reperfusion Impairs Mitochondrial Bioenergetics and Myocardial Function [PDF]

, 2008
Inhibition of Na+/H+ exchange (NHE) during ischemia reduces cardiac injury due to reduced reverse mode Na+/Ca2+ exchange. We hypothesized that activating NHE-1 at buffer pH 8 during ischemia increases mitochondrial oxidation, Ca2+ overload, and reactive ...
Aldakkak, Mohammed, Camara, Amadou K.S., Heisner, James S., Spence, Marisha, Stowe, David F.   +4 more
core   +1 more source

Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]

, 2017
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin, Bartunek, Jozef, Beerens, Manu, Bloch, Donald B, Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Caluwe, Ellen, Gillijns, Hilde, Janssens, Stefan P, Nathan, Daniel I, Scherrer-Crosbie, Marielle, Swinnen, Melissa, Tainsh, Robert E, Vandenwijngaert, Sara, Walravens, Ann-Sophie   +15 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

A cortical potential reflecting cardiac function [PDF]

, 2007
Emotional trauma and psychological stress can precipitate cardiac arrhythmia and sudden death through arrhythmogenic effects of efferent sympathetic drive. Patients with preexisting heart disease are particularly at risk.
Angell James, Augustine, Brooks, Chandler, Chang, Craig, Craig, Craig, Critchley, Critchley, Critchley, Critchley, D. Bradbury, D. Brull, D. Groves, D. R. Holdright, DAMASIO, Delorme, Dirlich, Fagius, Giannattasio, H. D. Critchley, James, Kohl, Lampert, Lane, Lanza, M. A. Gray, Montoya, Moss, Nei, Oppenheimer, Oppenheimer, Oppenheimer, Oppenheimer, Oppenheimer, Oppenheimer, P. M. Sutton, P. Taggart, Pollatos, Pollatos, Rosen, Rosen, Salo, Schandry, Schwartz, Taggart, Wallin, Zhang, Zhang   +49 more
core   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Glucosamine inhibits cardiomyocyte death induced by myocardial ischemia/reperfusion via OGT-RIPK3 axis

陆军军医大学学报
Objective To investigate the regulatory effect and specific mechanism of glucosamine (GlcN) on cardiomyoctye apoptosis and necroptosis after myocardial ischemia/reperfusion (I/R) injury.
DENG Li, ZHOU Liping, SU Jinfeng
doaj   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Training-induced gene expression plasticity in cardiac function and neural regulation for ultra-trail runners [PDF]

, 2015
This study aims to assess the gene regulatory response from a group of 16 athletes and to observe the plasticity induced by their training regime on the gene expression response after their participation in an 82km race.
Brotons, Daniel, Maqueda González, María de los Ángeles, Perera Lluna, Alexandre, Roca, Emma, Soria Fernández, José Manuel   +4 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Echocardiography Assessment of Cardiac Function in Adults Living with HIV: A Speckle Tracking Study in the Era of Antiretroviral Therapy [PDF]

, 2022
Oana Mirea, Mirela Manescu, Sorina Iordache, Andreea Marcu, Ionuţ Donoiu, Octavian Istrătoaie, Florentina Dumitrescu, Constantin Militaru   +7 more
openalex   +1 more source