Acta Obstetricia et Gynecologica Scandinavica, EarlyView.This study demonstrates that women with prior preeclampsia had significantly higher concentrations of PlGF when CT‐assessed coronary atherosclerosis was present years following the index pregnancy, whereas no difference was found for concentrations of sFlt‐1.
Signe Højstrup Bessing +11 more
wiley +1 more source
A Device-Free Respiratory Gating Technique for Dynamic CT Using Time-Density Curve Analysis: A Technical Report With Clinical Applications. [PDF]
CureusAkiyama N +3 more
europepmc +1 more source
Artificial Organs, EarlyView.Preventable geometric failure modes, such as outflow graft kinking and inflow malposition, frequently cause HeartMate 3 dysfunction. This study identifies these complications as key drivers of device‐related morbidity, highlighting the importance of optimized surgical positioning to ensure long‐term device performance and improved clinical outcomes ...
Ali Saad Merzah +17 more
wiley +1 more source
Modeling the spatiotemporal properties of crosstalk between RyR-mediated and IP<sub>3</sub>R-mediated local Ca<sup>2+</sup> release. [PDF]
Front Cell Dev BiolJones DC, Sobie EA.
europepmc +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Following the flow: in vivo imaging of fetal foramen ovale physiology using four-dimensional flow magnetic resonance imaging with doppler ultrasound gating. [PDF]
Radiol Case RepGerstner Saucedo J +6 more
europepmc +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction. [PDF]
J Mol Cell Cardiol PlusHarper RL +14 more
europepmc +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source