Results 271 to 280 of about 470,992 (309)

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

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An evaluation of the cardiac index

American Heart Journal, 1966
Abstract The value of using the body surface area to correct cardiac output for body size (cardiac index) has been studied in several ways. Its historical development has been traced and an attempt made to point out the strengths and weaknesses of the early data.
Robert H. Eich, Robert H. Eich, Richard P. Cuddy, Richard P. Cuddy, William A. Vincent, William A. Vincent, Udomporn Kashemsant, Udomporn Kashemsant, Harold Smulyan, Harold Smulyan   +9 more
openaire   +2 more sources

Assessment of Cardiac Index in Anemic Patients

Chest, 2000
During isovolemic hemodilution, healthy individuals maintain oxygen consumption VO2 by identical increases in cardiac index (CI) and oxygen extraction ratio (O(2)ER). In critically ill patients, the relationship between CI and O(2)ER may be different. Patients with an altered cardiac function may have a decreased CI/O(2)ER ratio, whereas patients with ...
Yalavatti, Gangadhar, De Backer, Daniel, Vincent, Jean Louis   +2 more
openaire   +3 more sources

Use of cardiac index in pregnancy: Is it justified?

American Journal of Obstetrics and Gynecology, 1995
The aim of this study was to test the hypothesis that standardization of cardiac output in pregnancy by correcting for body surface area, and thus obtaining cardiac index, is justified.Cardiac output was determined by thoracic electrical bioimpedance monitoring in 78 pregnant women; recordings were made at 1-month intervals from the first antenatal ...
Hein W. Bruinse, Ingeborg van der Tweel, Johannes J. Duvekot, A. Carla C. van Oppen   +3 more
openaire   +3 more sources

General index for the assessment of cardiac function

The American Journal of Cardiology, 1972
Abstract The concept of a “normalized velocity” was employed to provide a uniform approach for the assessment of cardiac function. In particular, the quantities [(dp/dt/)/p]max, [(dV/dt/)/V]max and [t(dl/dt/)/l]max were applied to data taken from 89 studies in 71 infants, children and young adult patients.
Israel Mirsky, R. Curtis Ellison, Andre Pasternac   +2 more
openaire   +3 more sources

The effect of obesity on bioimpedance cardiac index

The American Journal of Surgery, 2005
Cardiac performance may be assessed noninvasively at the patient's bedside by using thoracic bioimpedance. However, it is unclear if this technique can be used reliably in critically injured obese patients because of increased body habitus and chest wall mass.A prospectively maintained database was used to identify all trauma patients admitted to the ...
Carlos V.R. Brown, Demetrios Demetriades, Matthew J. Martin, Kenneth S. Azarow, Linda Chan, Charles C.J. Wo, William C. Shoemaker   +6 more
openaire   +3 more sources