Results 81 to 90 of about 6,309,608 (342)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces postoperative complications after major abdominal surgery: a multi-center, prospective, randomized study

Critical Care, 2013
IntroductionSeveral single-center studies and meta-analyses have shown that perioperative goal-directed therapy may significantly improve outcomes in general surgical patients.
C. Salzwedel, J. Puig, A. Carstens, B. Bein, Z. Molnár, K. Kiss, A. Hussain, J. Belda, M. Kirov, S. Sakka, D. Reuter   +10 more
semanticscholar   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Clinical study: the impact of goal-directed fluid therapy on volume management during enhanced recovery after surgery in gastrointestinal procedures

Acta Biochimica Polonica
Background: Goal-directed fluid therapy, as a crucial component of accelerated rehabilitation after surgery, plays a significant role in expediting postoperative recovery and enhancing the prognosis of major surgical procedures.Methods: In line with this,
Ming Gao, Minggan Chen, Gang Dai, Dengfeng Zhu, Yiting Cai   +4 more
doaj   +1 more source

Impact of body mass index on the outcomes in cardiac surgery

Journal of Cardiothoracic and Vascular Anesthesia, 2016
Objectives Body mass index (BMI) is commonly used in obesity classification as a surrogate measure and obesity is associated with a cluster of risk factors for cardiovascular disease.
Mei Gao, Jianzhong Sun, Nilas J. Young, D. Boyd, Zane Atkins, Zhongmin Li, Qian Ding, J. Diehl, Hong Liu   +8 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Ischemic Preconditioning for Off-Pump Isolated Coronary Artery Bypass Grafting

Український журнал серцево-судинної хірургії, 2020
National Amosov Institute of Cardiovascular Surgery is a pioneer in implementation of coronary artery bypass grafting (CABG) in our country [1]. Since 2000, over 13,000 off-pump CABG operations were performed in our clinic [2].
N. Ioffe, S. Salo, M. Rudenko
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Association of Change in N-Terminal Pro-B-Type Natriuretic Peptide Following Initiation of Sacubitril-Valsartan Treatment With Cardiac Structure and Function in Patients With Heart Failure With Reduced Ejection Fraction.

Journal of the American Medical Association (JAMA), 2019
Importance In patients with heart failure and reduced ejection fraction (HFrEF), treatment with sacubitril-valsartan reduces N-terminal pro-b-type natriuretic peptide (NT-proBNP) concentrations. The effect of sacubitril-valsartan on cardiac remodeling is
MD JamesL.JanuzziJr, PhD MargaretF.Prescott, Mdmphmba JavedButler, Mdmhs G.MichaelFelker, MD AlanS.Maisel, KevinMcCague, PhD AlexanderCamacho, Mdmph IleanaL.Piña, MD RicardoA.Rocha, Mdmph AmilM.Shah, PharmD KristinM.Williamson, MD ScottD.Solomon, PrescottButler Felker Januzzi, Pina Maisel, S. Rocha, McCague, Camacho, Camacho McCague, CamachoRocha Williamson Butler, ButlerFelker Prescott, Rocha Maisel, S. Williamson   +21 more
semanticscholar   +1 more source

Myocardial Work Index in Professional Football Players: A Novel Method for Assessment of Cardiac Adaptation

, 2023
Background: The global myocardial work index (GWI), a novel, valid, and non-invasive method based on speckle-tracking echocardiography, could provide value for calculating left ventricular (LV) function and energy consumption in athletes.
Pedrero Tomé, Roberto, Elena Refoyo, Celada, Oscar Luis, Refoyo, Elena, Roberto Pedrero-Tomé, de la Fuente, Ana, Jose María Villalón, García Yébenes, Manuel, Beltrán, Almudena, Diaz-Gonzalez, Leonel, Troya, Jesús, Villalón, Jose María, Pedrero-Tome, Roberto, Almudena Beltrán, Ana de la Fuente, Díaz González, Leonel, Leonel Díaz-González, Manuel García-Yébenes, Oscar Luis Celada, Fuente, Ana de la, Jesús Troya, Garcia-Yebenes, Manuel   +21 more
core   +1 more source