Results 51 to 60 of about 126,909 (281)

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

A permeabilized cell model for studying cell division: a comparison of anaphase chromosome movement and cleavage furrow constriction in lysed PtK1 cells. [PDF]

, 1981
After lysis in a Brij 58-polyethylene glycol medium, PtK1 cells are permeable to small molecules, such as erythrosin B, and to proteins, such as rhodamine-labeled FAB, myosin subfragment-1, and tubulin.
CANDE, W. Zacheus, McDonald, K, Meeusen, R   +2 more
core   +2 more sources

Contemporary Diagnosis and Management of Hypertrophic Cardiomyopathy: The Role of Echocardiography and Multimodality Imaging

Journal of Cardiovascular Development and Disease, 2022
Hypertrophic cardiomyopathy (HCM) is an underdiagnosed genetic heart disease with an estimated prevalence of 0.2–0.5%. Although the prognosis of HCM is relatively good, with an annual general mortality of ~0.7%, some patients have an increased risk of ...
Takeshi Kitai, Andrew Xanthopoulos, Shoko Nakagawa, Natsuko Ishii, Masashi Amano, Filippos Triposkiadis, Chisato Izumi   +6 more
doaj   +1 more source

Pharmacological therapy of acute heart failure: what is available now and what is expected in future

Вестник анестезиологии и реаниматологии, 2020
The objective: to present an overview of current approaches to pharmacological therapy of acute heart failure (AHF).Results: the discussion focuses on drugs that are currently available and being actively studied in ongoing clinical trials. Disadvantages
A. A. Eremenko
doaj   +1 more source

Current and emerging perspectives on pathophysiology, diagnosis, and management of hypertrophic cardiomyopathy

Hellenic Journal of Cardiology, 2023
Hypertrophic cardiomyopathy (HCM) is the most common genetically inherited cardiomyopathy with an autosomal dominant inheritance pattern. A disease-causing gene is found between 34% and >60% of the times and the two most frequently mutated genes, which ...
Ilias K. Gartzonikas, Katerina K. Naka, Aris Anastasakis   +2 more
doaj   +1 more source

Cardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Week. [PDF]

, 2019
The term "inotrope" is familiar and intimately connected with pharmaceuticals clinically used for treatment of low cardiac output with cardiogenic shock.
Adams, KF, Allen, LA, Francis, GS, Gottlieb, SS, Lancellotti, P, Psotka, MA, Rosano, GMC, Teerlink, JR   +7 more
core   +2 more sources

Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States

Journal of Molecular Biology, 2021
In addition to a conventional relaxed state, a fraction of myosins in the cardiac muscle exists in a low-energy consuming super-relaxed (SRX) state, which is kept as a reserve pool that may be engaged under sustained increased cardiac demand. The conventional relaxed and the super-relaxed states are widely assumed to correspond to a structure where ...
Sampath K, Gollapudi, Weikang, Ma, Srinivas, Chakravarthy, Ariana C, Combs, Na, Sa, Stephen, Langer, Thomas C, Irving, Suman, Nag   +7 more
openaire   +2 more sources

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

RIP1/RIP3/MLKL Mediates Myocardial Function Through Necroptosis in Experimental Autoimmune Myocarditis

Frontiers in Cardiovascular Medicine, 2021
Cardiomyopathy often leads to dilated cardiomyopathy (DCM) when caused by viral myocarditis. Apoptosis is long considered as the principal process of cell death in cardiomyocytes, but programmed necrosis or necroptosis is recently believed to play an ...
Yujing Wu, Yujing Wu, Yujing Wu, Zhenzhong Zheng, Zhenzhong Zheng, Xiantong Cao, Qing Yang, Qing Yang, Vikram Norton, Avner Adini, Amit K. Maiti, Irit Adini, Hao Wu   +12 more
doaj   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source