Results 51 to 60 of about 910,276 (348)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants.

PLoS ONE, 2019
AimWe hypothesized that compromised cardiac output in asphyxiated infants may influence on the rate of disappearance of lactate due to insufficient perfusion.MethodsThe study was a prospective, observational study, where infants with perinatal asphyxia ...
Vibeke Ramsgaard Eriksen, Simon Trautner, Gitte Holst Hahn, Gorm Greisen   +3 more
doaj   +1 more source

Análise da técnica de takeuchi usada para o tratamento da origem anômala da artéria coronária esquerda do tronco pulmonar Analysis of the takeuchi procedure for the treatment of anomalous origin of the left coronary artery from the pulmonary artery

Arquivos Brasileiros de Cardiologia, 2008
FUNDAMENTO: Avaliação dos casos de origem anômala da artéria coronária esquerda do tronco pulmonar operados com a técnica de Takeuchi, analisando o resultado cirúrgico imediato e tardio e a morbidade destes pacientes.
Andrea Weirich Lenzi, Leo Solarewicz, Wanderley Saviollo Ferreira, Fábio Sallum, Nelson Itiro Miyague   +4 more
doaj   +1 more source

Automatic calcium scoring in low-dose chest CT using deep neural networks with dilated convolutions

, 2018
Heavy smokers undergoing screening with low-dose chest CT are affected by cardiovascular disease as much as by lung cancer. Low-dose chest CT scans acquired in screening enable quantification of atherosclerotic calcifications and thus enable ...
de Jong, Pim A., de Vos, Bob D., Išgum, Ivana, Lessmann, Nikolas, van Ginneken, Bram, Viergever, Max A., Zreik, Majd   +6 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Avaliação da força muscular respiratória e da função pulmonar em pacientes com insuficiência cardíaca Evaluation of respiratory muscle strength and pulmonary function in heart failure patients

Arquivos Brasileiros de Cardiologia, 2007
FUNDAMENTO: O termo insuficiência cardíaca (IC) refere-se à falha do coração em bombear sangue para suprir as necessidades do organismo. A função pulmonar e os músculos respiratórios podem estar afetados e os sintomas típicos apresentados pelos pacientes
Luiz Alberto Forgiarini Junior, Angélica Rubleski, Garcia Douglas, Juliana Tieppo, Rafael Vercelino, Adriane Dal Bosco, Mariane Borba Monteiro, Alexandre Simões Dias   +7 more
doaj   +1 more source

Clinical efficacy of levosimendan vs milrinone in preventing low cardiac output syndrome following pediatric cardiac surgery

Annals of Cardiac Anaesthesia, 2021
Background: Prophylactic milrinone is commonly used to prevent Low Cardiac Output Syndrome (LCOS) after pediatric cardiac surgery. This study compares the use of levosimendan with milrinone when used as the primary inotrope following pediatric cardiac ...
Kaushik Jothinath, Soundaravalli Balakrishnan, Vijayakumar Raju, Shoba Menon, Jenit Osborn   +4 more
doaj   +1 more source

Metabolically exaggerated cardiac reactions to acute psychological stress revisited [PDF]

, 2009
The reactivity hypothesis postulates that large magnitude cardiovascular reactions to psychological stress contribute to the development of pathology. A key but little tested assumption is that such reactions are metabolically exaggerated.
Allen, Barnett, Blix, Brener, Brosschot, Carroll, Carroll, Carroll, Carroll, Carroll, Cybulski, Cybulski, de Boer, Gronwall, Hastrup, Kamarck, Kubicek, Langer, Light, Lovallo, Lynch, Markovitz, Obrist, Ring, Ring, Schmidt, Schuler, Schwartz, Sherwood, Sherwood, Sims, Steptoe, Stoney, Stromme, Treiber, Turner, Veldhuijzen van Zanten, Waldstein, Willemsen   +38 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Extracorporeal Membrane Oxygenation for Low Cardiac Output Condition after Pediatric Heart Transplantation

Archives of Anesthesia and Critical Care, 2023
No Abstract  No Abstract   No ...
Ali Jabbari, Behrang Nooralishahi, Alireza Jahangiri Fard   +2 more
doaj   +1 more source