Results 221 to 230 of about 3,775,130 (409)
An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari+20 more
wiley +1 more source
How cardiac output is controlled in a Fontan circulation: an update. [PDF]
Gewillig M+4 more
europepmc +1 more source
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou+18 more
wiley +1 more source
Agreement of concomitant cardiac output measurement by thoracic bio-impedance and inert gas rebreathing in healthy subjects. [PDF]
Filaire L+6 more
europepmc +1 more source
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao+13 more
wiley +1 more source
Effect of Hypocapnia on Cardiac Output During Anesthesia [PDF]
Richard A. Theye+2 more
openalex +1 more source
Standardization and quality control of the introduction of a noninvasive cardiac output monitor for pregnancy measurements in a low- and middle-income country. [PDF]
Perry H+10 more
europepmc +1 more source
Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation
Detecting internal abnormalities in soft matter remains challenging due to its heterogeneous nature. This study introduces a method that infers hidden physical properties by matching observed deformation with simulation through parallel Bayesian optimization.
Huanyu Yang+9 more
wiley +1 more source