Results 51 to 60 of about 451,923 (312)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Cardiac output limits maximal oxygen consumption, but what limits maximal cardiac output?

Experimental Physiology
Maximal oxygen uptake/consumption is an important variable determining exercise performance. It is generally considered to be limited largely, but not exclusively, by maximal cardiac output (CO), which limits the ability of heart to pump oxygen‐rich ...
Ilkka Heinonen
doaj   +1 more source

Perfusion of the interventricular septum during ventilation with positive end-expiratory pressure (PEEP) [PDF]

, 1991
Objective: To determine whether regional hypoperfusion of the interventricular septum occurs during ventilation with positive end-expiratory pressure. Design: Animal study. Animals: Anesthetized, closed chest dogs (n = 8).
Iber, Volker, Messmer, Konrad, Schosser, Rudolf, Schwickert, Christiane, Spengler, Peter, Weiss, Michaela, Zwißler, Bernhard   +6 more
core  

The normal ranges of cardiovascular parameters measured using the ultrasonic cardiac output monitor [PDF]

, 2017
The ultrasonic cardiac output monitor (USCOM) is a noninvasive transcutaneous continuous wave Doppler method for assessing hemodynamics. There are no published reference ranges for normal values in adults (aged 18– 60 years) for this device.
Cattermole, Giles N, Chan, Cangel P.Y, Chan, Stewart S.W, Graham, Colin A, Ho, Grace Y.L, Lau, Peach W.S, Leung, P.Y Mia, Rainer, Timothy H, Smith, Brendan E   +8 more
core   +3 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Airway pressure as a predictor of cardiac output reduction in prone position spine surgery: A prospective observational study

Journal of the Formosan Medical Association
Background: The prone position is commonly used in surgical procedures and is known to cause significant hemodynamic changes, particularly a reduction in cardiac output. This study aimed to explore the relationship between intra-abdominal pressure (IAP),
Yi-Ping Wang, Ping-Ju Chen, Huei-Lien Yu, Jia-Fang Syu, Chun-Yu Wu, Tsung-Ta Wu   +5 more
doaj   +1 more source

Bioreactance is a reliable method for estimating cardiac output at rest and during exercise [PDF]

, 2015
Background: Bioreactance is a novel noninvasive method for cardiac output measurement that involves analysis of blood flow-dependent changes in phase shifts of electrical currents applied across the thorax.
Cassidy, Sophie, Houghton, David, Jakovljevic, Djordje, Jones, Thomas, MacGowan, Guy, Trenell, Michael   +5 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Calibrated cardiac output monitoring versus standard care for fluid management in the shocked ICU patient: a pilot randomised controlled trial

Journal of Intensive Care, 2019
Background Despite the evidence for calibrated cardiac monitored devices to determine fluid responsiveness, there is minimal evidence that the use of cardiac output monitor devices leads to an overall change in IV fluid use.
Timothy G. Scully, Robert Grealy, Anthony S. McLean, Sam R. Orde   +3 more
doaj   +1 more source

Computer circuit calculates cardiac output [PDF]

, 1966
Electronic circuitry automatically calculates cardiac output.
Mc Cullough, C. E.
core   +1 more source