Results 51 to 60 of about 3,166,365 (300)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops.
Corey W. Bown, Dandan Liu, Katie E. Osborn, Deepak K. Gupta, Lisa A. Mendes, Kimberly R. Pechman, Timothy J. Hohman, Thomas J. Wang, Katherine A. Gifford, Angela L. Jefferson   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cardiac output estimation based on arterial and venous blood gas analysis: proposal of a monitoring method

Anaesthesiology Intensive Therapy, 2021
Hemodynamic optimization is vital in high risk surgical patients or in high risk surgical procedures. The main objective of hemodynamic management is to maintain tissue perfusion and preserve aerobic metabolism through a cardiac output coupled with the ...
David Santiago Giraldo Gutiérrez, Juan José Velásquez Gutiérrez, Joaquín Octavio Ruiz-Villa   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC) : a pragmatic, cluster randomised controlled trial [PDF]

, 2014
Background: Mechanical chest compression devices have the potential to help maintain high-quality cardiopulmonary resuscitation (CPR), but despite their increasing use, little evidence exists for their effectiveness.
Cooke, MW, Deakin, Charles D., Whitfield, R, Lamb, Sarah E, Perkins, Gavin D., Gates, S, Lamb, S. E., Smyth, M, Slowther, Anne, Deakin, CD, Lamb, Sarah E., Pocock, H, Black, JJM, Wright, John, Han, K, Horton, J, Whitfield, Richard, Black, John J. M., Black, John J M, Han, Kyee, Cooke, Matthew, Gates, Simon, Lamb, Sarah, Horton, Jessica, Wright, J, Pocock, Helen, Lamb, SE, Lal, R, Williams, A, Quinn, Tom, Woollard, M, Lall, Ranjit, Paramedic trial Collaborators,, Slowther, Anne-Marie, Black, JJ, Cooke, Matthew W., Williams, Amanda, Slowther, AM, Carson, A, Perkins, GD, Smyth, Michael A., Lall, R, Carson, Andy, Cooke, Matthew W, Smyth, Mike, Black, John J.M., Woollard, Malcolm, Perkins, Gavin D, Quinn, T, Deakin, Charles D   +49 more
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Pulse Contour Methods to Estimate Cardiovascular Indices in Micro- And Hypergravity [PDF]

, 2013
Background: The importance of noninvasive health monitoring in space increased as a result of the long-duration missions on the International Space Station (ISS).
Beck, L., Limper, Ulrich, Gauger, Peter, Arai, Tatsuya   +3 more
core   +1 more source