Results 151 to 160 of about 56,112 (262)

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Leadless pacemaker implantation in real-world clinical practice: An Italian survey promoted by the AIAC (Italian Association of Arrhythmology and Cardiac Pacing). [PDF]

J Arrhythm
Rordorf R, De Regibus V, Bontempi L, De Ambroggi G, Mascioli G, Mazzone P, Anselmino M, Casella M, Lauretti M, Pelargonio G, Russo V, Vilotta M, Ziacchi M, Boriani G, Palmisano P, Themistoclakis S, D'Onofrio A, De Ponti R, AIAC Ricerca Investigator Network.   +18 more
europepmc   +1 more source

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes. [PDF]

Adv Sci (Weinh)
Chang Z, Wang B, Ren Q, Nie J, Guo B, Lu Y, Lu X, Zhang Y, Ji D, Lv Y, Rotenberg MY, Fang Y.   +11 more
europepmc   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Health and Well‐Being Beyond Residential Care: Implications for Extended Care Service Responses for Young People

Child &Family Social Work, EarlyView.
ABSTRACT Care leavers often encounter considerable health and well‐being challenges, underscoring the need for continued support into early adulthood. This small‐scale mixed‐methods study explored the health, well‐being and extended care experiences of participants in the South Australian Next Steps pilot program for residential care leavers, assessed ...
Sally‐Ann Keipert, Helen McLaren, Samuel Carpenter, Michelle Jones   +3 more
wiley   +1 more source

Prehospital Transcutaneous Cardiac Pacing in the United States: Treatment Epidemiology, Predictors of Treatment Failure, and Associated Outcomes. [PDF]

Prehosp Emerg Care
Smida T, Voges L, Crowe R, Scheidler J, Bardes J.   +4 more
europepmc   +1 more source

Exercise Snacks Are Feasible to Perform in the Real World and Improve Physical Capacity for Adults Living With Non‐Insulin Treated Type 2 Diabetes: A Randomised Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To investigate the feasibility and preliminary efficacy of a 12‐week remotely‐delivered exercise snacks (ES) intervention in adults with type 2 diabetes. Material and Methods Insufficiently active adults with type 2 diabetes (N = 69; 46 females; mean age ± SD: 58 ± 11 years) were randomised to an ES or mobility/stretching comparator group
Fiona J. Babir, Alexis Marcotte‐Chénard, Roderick E. Sandilands, Kaja Falkenhain, Noah Mulkewich, Hashim Islam, Seth F. McCarthy, Douglas L. Richards, Kenneth Madden, Joel Singer, Michael C. Riddell, Mary E. Jung, Martin J. Gibala, Jonathan P. Little   +13 more
wiley   +1 more source

An AI‐Driven H5P Training for Epilepsy Emergency Management Preparedness in Dental Education

European Journal of Dental Education, EarlyView.
ABSTRACT Background Deficiencies in knowledge and skills related to the management of medical emergencies in dental settings can adversely affect the clinical safety of patient safety. This intervention study evaluates the effect of the ‘Medical Emergencies in Dentistry: Epilepsy Management’ module delivered via the H5P platform on postgraduate dental ...
İlkem Gökçe, Özlem Sürel Karabilgin Öztürkçü, Ozan Karaca, Cihan Varol, Mukadder İnci Başer Kolcu   +4 more
wiley   +1 more source