Results 201 to 210 of about 760,458 (299)

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam   +3 more
wiley   +1 more source

A PARYLENE-BASED MEMS INTRAVASCULAR IMPLANT FOR WIRELESS CARDIAC PACING. [PDF]

open access: yesProc IEEE Int Conf Micro Electro Mech Syst
Shang KM, Hsiai T, Tai YC.
europepmc   +1 more source

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder   +7 more
wiley   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang   +4 more
wiley   +1 more source

Health and Well‐Being Beyond Residential Care: Implications for Extended Care Service Responses for Young People

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Care leavers often encounter considerable health and well‐being challenges, underscoring the need for continued support into early adulthood. This small‐scale mixed‐methods study explored the health, well‐being and extended care experiences of participants in the South Australian Next Steps pilot program for residential care leavers, assessed ...
Sally‐Ann Keipert   +3 more
wiley   +1 more source

DiaActive protocol: A randomized controlled trial of cognitive‐motor multicomponent exercise to reduce fall rate in older adults with diabetes

open access: yesDiabetic Medicine, EarlyView.
Abstract Introduction Older adults with diabetes have an increased risk of falls due to neuropathy, impaired bone health and cardiovascular disease, resulting in significant morbidity and mortality. Conventional fall‐prevention programmes primarily target strength and balance, while cognitive‐motor integration, essential for safe mobility in complex ...
Aksayan Arunanthy Mahalingasivam   +4 more
wiley   +1 more source

An AI‐Driven H5P Training for Epilepsy Emergency Management Preparedness in Dental Education

open access: yesEuropean Journal of Dental Education, EarlyView.
ABSTRACT Background Deficiencies in knowledge and skills related to the management of medical emergencies in dental settings can adversely affect the clinical safety of patient safety. This intervention study evaluates the effect of the ‘Medical Emergencies in Dentistry: Epilepsy Management’ module delivered via the H5P platform on postgraduate dental ...
İlkem Gökçe   +4 more
wiley   +1 more source

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