Results 41 to 50 of about 101,589 (306)

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

An intracardiac electrogram model to bridge virtual hearts and implantable cardiac devices

, 2017
Virtual heart models have been proposed to enhance the safety of implantable cardiac devices through closed loop validation. To communicate with a virtual heart, devices have been driven by cardiac signals at specific sites.
Ai, Weiwei, Allen, Nathan, Malik, Avinash, Patel, Nitish, Roop, Partha, Trew, Mark L.   +5 more
core   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Techniques for Identification of Left Ventricular Asynchrony for Cardiac Resynchronization Therapy in Heart Failure [PDF]

, 2005
The most recent treatment option of medically refractory heart failure includes cardiac resynchronization therapy (CRT) by biventricular pacing in selected patients in NYHA functional class III or IV heart failure. The widely used marker to indicate left
Peter, Schuster, Svein, Faerestrand
core  

Soft Ionic and Electronic Triboelectric Nanogenerators: Toward Attachable and Implantable Biomedical Applications

Advanced Materials, EarlyView.
This review provides an overview of triboelectric nanogenerator (TENG)–based biomedical applications by classifying studies into electronic and ionic systems across attachable and implantable platforms. It summarizes key material choices, device structures, and working mechanisms that characterize current TENG‐based research, and outlines six future ...
Kyongtae Choi, Jimin Park, Won Jun Song, Soohwan An, Seonggyu Choe, Byeong‐Rak Keum, Min Young Kim, Dae Hee Hwang, Young‐Geun Park, Sung‐Won Kim, Sangyul Baik, Gwang‐Bum Im, Younghoon Lee   +12 more
wiley   +1 more source

Novel SCN5A gene mutation in a patient affected by multifocal ectopic premature Purkinje‐related contractions syndrome

ESC Heart Failure
We report the case of a 36‐year‐old woman who presented to the emergency department complaining of palpitations and asthenia. Investigations showed frequent ventricular ectopy and severe left ventricular ejection fraction impairment.
Nicoletta Ventrella, Lorenzo Bianchini, Stefania Riva, Francesca Pizzamiglio, Maria Antonietta Dessanai, Fabrizio Tundo, Tommaso Sattin, Francesca De Lio, Selene Cellucci, Claudio Tondo   +9 more
doaj   +1 more source

Incidence and Predictors of Cardiac Arrhythmias in Patients With COVID-19

Frontiers in Cardiovascular Medicine, 2022
BackgroundCoronavirus disease 2019 (COVID-19) is a systemic disease caused by severe acute respiratory syndrome coronavirus 2. Arrhythmias are frequently associated with COVID-19 and could be the result of inflammation or hypoxia.
Sahar Mouram, Luigi Pannone, Anaïs Gauthey, Antonio Sorgente, Pasquale Vergara, Antonio Bisignani, Cinzia Monaco, Joerelle Mojica, Maysam Al Housari, Vincenzo Miraglia, Alvise Del Monte, Gaetano Paparella, Robbert Ramak, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Ströker, Juan Sieira, Pedro Brugada, Mark La Meir, Gian Battista Chierchia, Carlo de Asmundis   +21 more
doaj   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Impact of a Right Ventricular Impedance Sensor on the Cardiovascular Responses to Exercise in Pacemaker Dependent Patients [PDF]

, 2005
Background. The evaluation of the heart rate (HR) response to exercise is important for the assessment of the rate response algorithm of sensor-controlled pacemakers.
Corey, Tomczak, Edward, Busse, John, Tsang, Linnea, Cook, Robert, Haennel, Tada, Hiroshi, Wladyslaw, Wojcik   +6 more
core