Results 101 to 110 of about 89,005 (280)

Inflammatory Cytokines as Early Predictors of Weaning Failure From Extracorporeal Life Support

open access: yesArtificial Organs, EarlyView.
Levels of IL‐8 and IL‐6 and their dynamics are reliable early predictors of ECLS weaning failure. ABSTRACT Background Weaning from extracorporeal life support (ECLS) in patients with refractory shock still remains a complex decision. Despite considerable advances in ECLS management, reliable biomarkers to predict weaning success are still not available.
Kostiantyn Kozakov   +11 more
wiley   +1 more source

Risk Scores Validation: An Example in Cardiology

open access: yesEpidemiology, Biostatistics and Public Health
Introduction: Clinicians often make important decisions about patient care by estimating the likelihood of a particular disease, condition or event occurring. Prediction models are useful in this context.
Sara Bendotti   +11 more
doaj   +1 more source

Percutaneous Versus Surgical Cannulation for Femoro‐Femoral Venoarterial Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study on Cannulation‐Related Complications

open access: yesArtificial Organs, EarlyView.
Percutaneous femoro‐femoral V‐A ECMO cannulation was associated with more than a two‐fold lower risk of site bleeding and nearly a six‐fold lower risk of infection compared with surgical cut‐down, with no difference in limb ischemia. Absence of distal perfusion catheterization and larger arterial cannula size were additional modifiable ischemia risk ...
Axel Dimberg   +3 more
wiley   +1 more source

Prognostic Impact of No-Flow Time on 30-Day Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Who Received Extracorporeal Cardiopulmonary Resuscitation

open access: diamond, 2020
Naoto Murakami   +9 more
openalex   +2 more sources

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

Protocol summary and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial [PDF]

open access: green, 2021
Alistair Nichol   +17 more
openalex   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi   +19 more
wiley   +1 more source

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

open access: yesCell Proliferation, EarlyView.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang   +6 more
wiley   +1 more source

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