Results 191 to 200 of about 261,663 (299)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

open access: yesThe FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy   +7 more
wiley   +1 more source

Goals of Care: a framework in evolution

open access: yesInternal Medicine Journal, EarlyView.
Abstract The Goals of Care framework has been strongly advocated for and widely adopted in various healthcare institutions across Australia. While it has promoted awareness and perceptions around advanced care planning and treatment limitations, there remain concerns.
Benedict Tan
wiley   +1 more source

Real‐world evidence supports the safety and efficacy profile of luspatercept in clinically complex and heavily iron‐overloaded patients

open access: yes
British Journal of Haematology, EarlyView.
Barbara Gianesin   +29 more
wiley   +1 more source

Case for caution in expanding attention deficit hyperactivity disorder prescribing

open access: yesInternal Medicine Journal, EarlyView.
Abstract Expanding psychostimulant prescribing to general practitioners (GPs) addresses Australia's attention deficit hyperactivity disorder (ADHD) access crisis, but risks significant unintended consequences. This article highlights the cumulative risks of long‐term stimulant use and the danger of fragmented care models.
Max Hankin   +3 more
wiley   +1 more source

Relatives' Experiences of Circulatory Death Following Out‐of‐Hospital Cardiac Arrest and Their Hypothetical Perspectives on Organ Donation: A Qualitative Study

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore relatives' experiences of the circulatory death of a family member following out‐of‐hospital cardiac arrest and to explore their hypothetical perspectives on being asked to decide about organ donation in this situation. This study forms part of a broader initiative undertaken to assess the prerequisites for implementing ...
Gisela Vogel   +3 more
wiley   +1 more source

Prognostic Value of Small Coved‐Type ST‐Segment Area in Patients With Spontaneous Type 1 Brugada Syndrome

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
Electrical and structural abnormalities in Brugada syndrome lead to a smaller coved‐type ST‐segment area. A reduced ST‐segment area may identify patients at elevated risk of ventricular fibrillation. ABSTRACT Background Risk stratification in Brugada syndrome (BrS) remains challenging.
Nario Sano   +10 more
wiley   +1 more source

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