Results 181 to 190 of about 899,396 (308)

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Retraction: Influence of different colloid solutions on coagulation status in patients undergoing cardiac surgery: Volume therapy in cardiac surgery. [PDF]

Ann Card Anaesth
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Effect of exercise prehabilitation on days alive and out of hospital after cardiac surgery: a secondary analysis of the randomised PRE-habilitation for improving QUality of recovery after ELective cardiac surgery trial. [PDF]

BJA Open
Lau VNM, Yau DKW, Ng FF, Li VWS, Wong KKH, Wong CHL, Hou PY, Ho KM, Lee A.   +8 more
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Nationwide outcomes of cardiac surgery in patients with cannabis use disorder. [PDF]

J Cardiothorac Surg
Dewan KC, Mahboubi R, Xu S, Maigrot JA, An C, Zhou G, Ferre JLD, Koroukian SM, Weiss AJ, Soltesz EG.   +9 more
europepmc   +1 more source

Cardiac Magnetic Resonance-aided Ventricular Tachycardia Substrate Ablation Using a Novel Research Image-navigated Late-gadolinium Enhancement Sequence

Journal of Cardiovascular Magnetic Resonance
Evangelia Nyktari, MD, Sultana Kourtidou, MD, Konstantinos Letsas, MD, PhD, Athanasios Saplaouras, MD, Thomas Vrachliotis, MD, PhD, Spyridonas Zarkadoulas, Panagiotis Rozos, Karl Kunze, PhD, Michaela Schmidt, Michalis Efremidis, MD, PhD   +9 more
doaj   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Cardiac surgery timing on the prognosis of patients with infective endocarditis. [PDF]

J Cardiothorac Surg
Liu W, Li Y, Yang H, Wang J, Lan W, Li C, Tang Y.   +6 more
europepmc   +1 more source

Cardiac Surgery

, 2022
Pingping Song, Michael Holmes, G. Burkhard Mackensen   +2 more
openaire   +1 more source