Results 181 to 190 of about 6,755,732 (357)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

A Rare Case of Pyroglutamic Acidosis After Cardiac Surgery. [PDF]

Cureus
Alves I, Ranchordas S, Marques M.
europepmc   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Successful Heart Transplantation in a Woman With LMNA-Related Emery–Dreifuss Muscular Dystrophy: A Case Report and Literature Review

Case Reports in Transplantation
Giuseppe Fischetti, Lorenzo Giovannico, Massimiliano Carrozzini, Domenico Parigino, Luca Savino, Federica Mazzone, Nicola Di Bari, Massimo Padalino, Tomaso Bottio   +8 more
doaj   +1 more source

Spontaneous PICC migration after cardiac surgery: a case report. [PDF]

Eur Heart J Case Rep
Tsoumpelis JP, Martin SJ, Polomsky M.
europepmc   +1 more source

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

Advanced Science, EarlyView.
This study presents an empirical model that quantitatively predicts the step‐out frequency of screw‐type untethered magnetic robots (UMRs) in soft viscoelastic environments, including ex vivo brain tissue. By integrating key parameters into a dimensionless framework, the model enables estimation of robot performance across a range of biological ...
Leendert‐Jan W. Ligtenberg, Thijs J. van der Burg, Stijn Y. Kolkman, Santiago Saavedra Castano, David Fernandez Rivas, Anke Klingner, Roger M. L. M. Lomme, Lucas S. Joziasse, Dorothee Wasserberg, H. Remco Liefers, Doron Ben Ami, Udi Sadeh, Oded Shoseyov, Giulio Dagnino, Pascal Jonkheijm, Jurgen J. Fütterer, Stefano Stramigioli, J. Frank W. Nijsen, Michiel C. Warlé, Islam S. M. Khalil   +19 more
wiley   +1 more source

Can Paracorporeal Bi-VAD Improve the Outcome of a Patient Candidate for Heart Transplant?

Case Reports in Transplantation
Giuseppe Fischetti, Lorenzo Giovannico, Federica Mazzone, Nicola Di Bari, Domenico Parigino, Massimo Padalino, Tomaso Bottio   +6 more
doaj   +1 more source

Is Preoperative Serum Bicarbonate an Undervalued Risk Factor in Cardiac Surgery? [PDF]

J Cardiovasc Transl Res
Chorney W, Hinchion J.
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Prophylactic Methylprednisolone in Neonatal On-Pump Cardiac Surgery. [PDF]

Rev Cardiovasc Med
Gao P, Jin Y, Wang H, Zhang P, Wang W, Liu J, Feng Z, Ji B, Liu J, Hu J.   +9 more
europepmc   +1 more source