Results 221 to 230 of about 6,755,732 (357)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Albumin in Cardiac Surgery-Associated Acute Kidney Injury: Therapeutic Target or Epiphenomenon? [PDF]

Ann Card Anaesth
Kapoor MC.
europepmc   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Patients' Perception of Information Provision Regarding Complications in Cardiac Surgery: A Thematic Analysis. [PDF]

Ann Card Anaesth
Visschers NJG, Thio MSY, de Bot CMA, Noordzij PG, Rettig TCD.   +4 more
europepmc   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Cardiovascular Magnetic Resonance 3D LGE Imaging for Atrial Fibrillation Ablation understanding Left Atrial Structural Changes

Journal of Cardiovascular Magnetic Resonance
Evangelia Nyktari, MD, Sultana Kourtidou, MD, Athanasios Saplaouras, MD, Konstantinos Letsas, MD, PhD, Thomas Vrachliotis, MD, PhD, Panagiotis Rozos, Spyridonas Zarkadoulas, Michaela Schmidt, Karl Kunze, PhD, Michalis Efremidis, MD, PhD   +9 more
doaj   +1 more source

Takotsubo Cardiomyopathy After Cardiac Surgery: A Hidden Menace. [PDF]

JACC Case Rep
See SB, Chan IYH, Ho JYK, Wong RHL.
europepmc   +1 more source

The Society of Thoracic Surgeons 2018 Adult Cardiac Surgery Risk Models: Part 2-Statistical Methods and Results.

Annals of Thoracic Surgery, 2018
Sean M. O'Brien, Liqi Feng, Xia He, Y. Xian, Jeffrey P. Jacobs, V. Badhwar, P. Kurlansky, A. Furnary, J. Cleveland, K. Lobdell, C. Vassileva, Moritz C. Wyler von Ballmoos, V. Thourani, J. Rankin, J. Edgerton, R. S. D'Agostino, Nimesh D. Desai, F. Edwards, D. Shahian   +18 more
semanticscholar   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Cardiac Magnetic Resonance-aided Ventricular Tachycardia Substrate Ablation Using a Novel Research Image-navigated Late-gadolinium Enhancement Sequence

Journal of Cardiovascular Magnetic Resonance
Evangelia Nyktari, MD, Sultana Kourtidou, MD, Konstantinos Letsas, MD, PhD, Athanasios Saplaouras, MD, Thomas Vrachliotis, MD, PhD, Spyridonas Zarkadoulas, Panagiotis Rozos, Karl Kunze, PhD, Michaela Schmidt, Michalis Efremidis, MD, PhD   +9 more
doaj   +1 more source