Results 51 to 60 of about 6,755,732 (357)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Central versus peripheral VA ECMO for cardiogenic shock: an 8-year experience of a tertiary cardiac surgery center in Greece

Hellenic Journal of Cardiology
Background: Venoarterial extracorporeal membrane oxygenation (VA ECMO) has emerged as an effective rescue therapy in patients with cardiogenic shock refractory to standard treatment protocols, and its use has been rising worldwide in the last decade ...
Michael Antonopoulos, Antigone Koliopoulou, Dimitrios Elaiopoulos, Kyriaki Kolovou, Dimitra Doubou, Anna Smyrli, Prodromos Zavaropoulos, Nektarios Kogerakis, Sokratis Fragoulis, Konstantinos Perreas, Georgios Stavridis, Stamatis Adamopoulos, Themistocles Chamogeorgakis, Stavros Dimopoulos, Theodora Soulele, Ioannis Vlahodimitris, Thodoris Pitsolis, Maria Panoutsopoulou, Efterpi Lyberopoulou, Kyrillos Papadopoulos, Ioannis Kriaras, Konstantina Kolonia, Giorgos Kostantinou, Maria Chronaki, Eleni Tzatzaki, Charalambia Kinti, Effrosini Prasinou, Sophia Mathioudaki, Ioanna Avgerinou, Panagiotis Kossivas, Chryssa Panagiotou, Dimitrios Poulis, Athanasios Ntinopoulos, Ioannis Mpardakos, Pigi Maraki, Ioannis Nenekidis, Chris Kapelios, Michael J. Bonios, Evangelos Leontiadis, Aggeliki Gkouziouta, Konstantinos Ieromonachos, Theofani Antoniou   +41 more
doaj   +1 more source

Heart transplantation of patients with ventricular assist devices: impact of normothermic ex-vivo preservation using organ care system compared with cold storage

Journal of Cardiothoracic Surgery, 2020
Background Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics and meticulous recipient preparation. Impact of normothermic ex-vivo preservation using OCS compared with cold storage (CS) for prolonged heart ...
Rymbay Kaliyev, Timur Lesbekov, Serik Bekbossynov, Zhuldyz Nurmykhametova, Makhabbat Bekbossynova, Svetlana Novikova, Assel Medressova, Nurlan Smagulov, Linar Faizov, Robertas Samalavicius, Yuriy Pya   +10 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid - a meta-analysis of randomised and observational trials of over 30.000 patients [PDF]

, 2013
Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.
Meybohm, Patrick, Julia Nierhoff (385973), Herrmann, Eva, Nierhoff, Julia, Zacharowski, Kai, Kai Zacharowski, Eva Herrmann, Patrick Meybohm, Patrick Meybohm (20539), Eva Herrmann (139197), Julia Nierhoff, Kai Zacharowski (77285)   +11 more
core   +1 more source

Impact of postoperative complications after cardiac surgery on long‐term survival

Journal of cardiac surgery, 2020
The impact of postoperative complications on long‐term survival is not well characterized. We sought to study the prevalence of postoperative complications after cardiac surgery and their impact on long‐term survival.
Siddharth Pahwa, A. Bernabei, H. Schaff, J. Stulak, K. Greason, A. Pochettino, R. Daly, J. Dearani, Gabor Bagameri, K. King, J. Viehman, J. Crestanello   +11 more
semanticscholar   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Bone Marrow Culture-Derived Conditioned Medium Recovers Endothelial Function of Vascular Grafts following In Vitro Ischemia/Reperfusion Injury in Diabetic Rats

Stem Cells International, 2022
Ischemia/reperfusion injury (IRI) remains a challenge in coronary artery bypass grafting (CABG). Diabetic patients with coronary artery disease are more likely to require CABG and therefore run a high risk for cardiovascular complications.
Sevil Korkmaz-Icöz, Gianluca Sistori, Sivakkanan Loganathan, Alex Ali Sayour, Paige Brlecic, Tamás Radovits, Maik Brune, Matthias Karck, Gábor Szabó   +8 more
doaj   +1 more source

Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial

Intensive Care Medicine, 2017
PurposeCare bundles are recommended in patients at high risk for acute kidney injury (AKI), although they have not been proven to improve outcomes. We sought to establish the efficacy of an implementation of the Kidney Disease Improving Global Outcomes ...
M. Meersch, C. Schmidt, A. Hoffmeier, H. Van Aken, C. Wempe, J. Gerss, A. Zarbock   +6 more
semanticscholar   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source