Results 111 to 120 of about 900,334 (369)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Mortality Risk After Cardiac Surgery: Application of Inscor in a University Hospital in Brazil's Northeast

Brazilian Journal of Cardiovascular Surgery
Objective: To apply the InsCor in patients undergoing cardiac surgery in a university hospital in Brazil's northeast. Methods: It is a retrospective, quantitative and analytical study, carried out at the University Hospital of the Federal University of ...
João Vyctor Silva Fortes, Mayara Gabrielle Barbosa e Silva, Thiago Eduardo Pereira Baldez, Marina de Albuquerque Gonçalves Costa, Luan Nascimento da Silva, Renata Silva Pinheiro, Zullma Sampaio Fecks, Daniel Lago Borges   +7 more
doaj   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

Advanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source

A Ward teaching unit on the care of the Cardiac patient [PDF]

, 1950
Thesis (Ed.M.)--Boston ...
Nassar, Leenda Mary
core   +1 more source

Evidence update on prevention of surgical site infection [PDF]

, 2015
Purpose of review: surgical site infection (SSI) is a common health care associated infection and complicates up to 10-20% of operations with considerable health care resources.
Astagneau, Bayat, Blackham, Bonds, Bunn, Cabaluna, Daoud, Darouiche, Edmiston, Fry, Gheorghe, Grauhan, Jakobsson, Kamel, Kent, Kirby, Krieger, Leaper, Leaper, Leaper, Leaper, Leaper, Leaper, Lyytikainen, Matatov, Melling, Pauli, Pinkney, Richet, Sanchez-Manuel, Stannard, Strecker, Tanner, Tanner, Taylor, Thibon, Togioka, Turtiainen, Ubbink, Wang, Webster, Williams, Yokoe   +42 more
core   +1 more source

Population Pharmacokinetics of Vancomycin in the Pediatric Cardiac Surgical Population.

The Journal of Pediatric Pharmacology and Therapeutics, 2019
OBJECTIVE Vancomycin is often used in the pediatric cardiac surgical population, but few pharmacokinetic data are available to guide dosing. METHODS A retrospective, population pharmacokinetic study was performed for patients 400.
B. Moffett, K. Reséndiz, Jennifer L. Morris, A. Akcan-Arikan, P. Checchia   +4 more
semanticscholar   +1 more source

Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model

Advanced Healthcare Materials, EarlyView.
A modular, triple‐action titanium implant is developed to prevent implant‐associated infections by repelling bacteria, killing pathogens, and enhancing tissue integration. Coatings with phage cocktails targeting P. aeruginosa and S. aureus show significant bacterial reduction and improved survival in a mouse sepsis model.
Martin Stark, Fereshteh Bayat, Sara Rahmani, Mathura Thirugnanasampanthar, Taylor Kramer, Elise Schwarz, David Wilson, Jeffrey I. Weitz, Zeinab Hosseinidoust, Tohid F. Didar   +9 more
wiley   +1 more source

A comparison of third-generation semi-invasive arterial waveform analysis with thermodilution in patients undergoing coronary surgery [PDF]

, 2012
Uncalibrated semi-invasive continous monitoring of cardiac index (CI) has recently gained increasing interest. The aim of the present study was to compare the accuracy of CI determination based on arterial waveform analysis with transpulmonary ...
Bein, Berthold, Broch, Ole, Grünewald, Matthias Lars, Malbrain, Manu, Meybohm, Patrick, Renner, Jochen, Schöttler, Jan, Steinfath, Markus   +7 more
core   +2 more sources

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Control of hyperglycaemia in paediatric intensive care (CHiP): study protocol. [PDF]

, 2010
BACKGROUND: There is increasing evidence that tight blood glucose (BG) control improves outcomes in critically ill adults. Children show similar hyperglycaemic responses to surgery or critical illness.
A Ceriello, A Ceriello, A Ceriello, A Chiaretti, A Rovlias, A Russo, A Russo, AA Ferrando, AA Ferrando, Allan Goldman, Ann Truesdale, AP Furnary, AP Furnary, B Halverson-Steele, CK Rayner, Claire Snowdon, D Ardigo, D Ardigo, D Ardigo, D Field, DA Schoenfeld, DC Angus, DC Angus, Deborah Percy, Diana Elbourne, Duncan Macrae, Elizabeth Allen, EV Faustino, G Paret, G Van den Berghe, G Van den Berghe, Helen Betts, J Lacroix, JL Haybittle, JM Hoxworth, John Pappachan, K Esposito, K Katsura, K Malmberg, K Malmberg, Kevin Morris, KJ Jenkins, LM McManus, M Cornblath, MAQ Curley, Margrid Schindler, Mark Peters, MF Oliver, Michael Broadhead, MM Gearhart, NJ Hall, P Lange, PA Li, Paul Baines, Peter-Marc Fortune, R Peto, RE Anderson, RG Branco, Richard Grieve, Robert Tasker, Roger Parslow, S Leteurtre, S Yendamuri, SE Capes, SE Capes, Simon Nadel, Tara Quick, The Acute Respiratory Distress Syndrome Network, TM Vriesendorp, TN Pham, UN Das, UN Das, UN Das, V Srinivasan, WA Pulsinelli, WD Dietrich, Zdenek Slavik   +76 more
core   +5 more sources