Results 131 to 140 of about 900,334 (369)

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Experience of treatment of prosthetic valve endocarditis: a retrospective single-center cross-sectional study

São Paulo Medical Journal, 2018
BACKGROUND: The aim of this study was to describe the experience of treatment of early prosthetic valve endocarditis at a heart center. DESIGN AND SETTING: Retrospective single-center study on data collected from electronic medical records covering ...
Matheus de Oliveira Andrade, Gabriel Elias Salmen Raffoul, Murilo Teixeira Macedo, Claudia Neto Gonçalves Neves da Silva, Maria Aparecida Santos Teixeira, Sônia Jaciara Neto Pontes, Mauricio Daher, Claudio Ribeiro da Cunha, Fernando Antibas Atik   +8 more
doaj   +1 more source

Prediction of operative mortality for patients undergoing cardiac surgical procedures without established risk scores. [PDF]

J Thorac Cardiovasc Surg, 2023
Ong CS, Reinertsen E, Sun H, Moonsamy P, Mohan N, Funamoto M, Kaneko T, Shekar PS, Schena S, Lawton JS, D'Alessandro DA, Westover MB, Aguirre AD, Sundt TM.   +13 more
europepmc   +1 more source

Robust pH Sensing Using a Graphene Oxide and Covalent Organic Frameworks Composite for Gastro‐esophageal Reflux Disease Diagnosis

Advanced Healthcare Materials, EarlyView.
A stable composite pH sensor is developed by coating graphene oxide (GO) nanosheets with covalent organic frameworks (COFs) to improve stability and sensitivity in acidic environments. The GO/COFs sensor demonstrates high selectivity, linearity, and biocompatibility, offering a promising strategy for continuous pH monitoring in gastro‐esophageal reflux
Ahmed H. M. Salem, Jianhui Zhang, Ashley Lam, Haowei Wang, Umber Cheema, Laurence B. Lovat, Manish K. Tiwari   +6 more
wiley   +1 more source

A rare neurological complication after a cardiac surgical procedure [PDF]

, 2007
Ingrid Porubčinová, František Sabol, Jana Jevčáková   +2 more
openalex   +1 more source

Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Advanced Healthcare Materials, EarlyView.
A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li, Jiahui Li, Hasan Al Faruque, Paul Shami, Birgit Knoechel, Jens Lohr, Douglas Sborov, Jiyuan Yang, Jindřich Kopeček   +8 more
wiley   +1 more source

Mean platelet volume-to-platelet count ratio after elective cardiac surgical procedures is superior in reflecting platelets metabolic hyperactivity compared to other routine morphological platelet indices: A preliminary report. [PDF]

Cardiol J, 2021
Perek B, Rzymski P, Komosa A, Olasińska-Wiśniewska A, Puślecki M, Jemielity M, Lesiak M, Aboul-Hassan SS, Stankowski T, Xia Z, Stelmark K, Siller-Matula J, Poniedziałek B.   +12 more
europepmc   +1 more source

General Hospitals, Specialty Hospitals and Financially Vulnerable Patients [PDF]

, 2009
Examines whether specialty hospitals draw well-insured patients away from general and safety-net hospitals, reducing their ability to cross-subsidize less profitable services and uncompensated care, in three cities.
Ann Tynan, Elizabeth A. November, Hoangmai H. Pham, Johanna R. Lauer, Peter Cram   +4 more
core  

Outcomes for Surgical Treatment of Atrial Fibrillation Using Cryoablation During Concomitant Cardiac Procedures [PDF]

, 2010
Naima M. Rahman, Richard B. Chard, Stuart P. Thomas   +2 more
openalex   +1 more source

A Comprehensive Review of Clinical Studies on Bacterial Cellulose: From the Earliest Uses to Contemporary Innovations

Advanced Healthcare Materials, EarlyView.
Bacterial cellulose has undergone a transformative journey from early applications to its role in advanced regenerative medicine. The review has a pedagogical ambition, offering clear pathways for future research and clinical adoption. Harmonizing regulatory standards and conducting larger, well‐designed clinical trials with standardized endpoints will
Thomas Meslier, Justin Christopher D'Antin, Gemma Julio, Anna Roig   +3 more
wiley   +1 more source